An individual with Huntington disease has two normal parents. What are plausible explanations for this pattern of inheritance? Check all that apply. Check All That Apply A spontaneous mutation occurred in the mother's germline to produce a mutant HD allele. A spontaneous mutation occurred in the mother's germline to produce a mutant HD allele. A spontaneous mutation occurred in the father's germline to produce a mutant HD allele. A spontaneous mutation occurred in the father's germline to produce a mutant HD allele. A spontaneous mutation occurred in the individual's germline to produce a mutant HD allele. A spontaneous mutation occurred in the individual's germline to produce a mutant HD allele. Huntington disease shows incomplete penetrance.

Answers

Answer 1

Answer and Explanation:

The Huntington disease is caused by a mutation in the gene that codifies for the Huntingtin protein (Htt). The mutation produces an altered form of the protein leading to the neuron´s death in certain areas of the brain.

The Huntington disease characterizes for being,

Hereditary, passing from generation to generation. To express the disease, a person must have been born with an altered gene. Autosomal, affecting men and women equally, because the mutated gene is located on an autosomal chromosome.Dominant, which means that by getting only one copy of the altered gene coming from any of the parents, the receiving person will express the disease. The mutation in the gene dominates over the normal gene copy. Expressed by heterozygosis. Most people affected by the disease are heterozygous, with a normal copy and a mutated copy.

There are just a few cases all around the world (3% approximately) in which the disease is expressed with no family history. The progenitors are not affected by the mutation. These cases are very rare and are called "de-novo" mutations. A new mutation is spontaneously produced and it is not inherited from any of the parentals. It consists of an increase in the number of CAG repetitions. In a normal person, the number of CAG repetitions is less than 35. When there are 40 or more repetitions it occurs the disease. But when there are between 35 and 39 repetitions, the penetrance of the disease is incomplete. This is a "gray zone". Those alleles that fall in the gray zone are unstable and might produce the HD. Individuals with these unstable alleles have a tendency to increase the number of repetitions from generation to generation until the number reaches 40 repetitions and the person expresses the disease. This usually occurs in the paternal germinal line, as it is particularly unstable in sperm and probably meiosis greatly affects their instability, causing an increase in the number of CAG repeats.


Related Questions

Why do predator populations follow the cycles of prey populations?

Answers

Answer: Food abundance

Explanation: If prey animals increase in number, predator numbers increase, if prey animal numbers decrease, so do the predator numbers

Because the cell membrane is made of two layers of lipids it is called a..?

Answers

Answer:

The lipid bilayer.

Explanation:

It is a thin polar membrane made of two layers of lipid molecules. These membranes are flat sheets that form a continuous barrier around all cells.

Cell membrane is made of two layers of lipids it is called lipid bilayer.

What is lipid bilayer?

The lipid bilayer is a fundamental component of all cell membranes. It is vital for identifying cell boundaries because of the barrier that its structural components offer.

The structure is called a "lipid bilayer" because there are two layers of fat cells arranged in two sheets, and the lipid bilayer, which surrounds all cells and provides the structure of the cell membrane, is usually about five nanometers thick.

The lipid bilayer's structural makeup explains how it acts as a barrier. Lipids are fats that are soluble in oil but not in water. The lipid bilayer's structure is provided by two crucial areas of a lipid.

Therefore, Cell membrane is made of two layers of lipids it is called lipid bilayer.

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What is the role of the gametophyte in fernsg?

Answers

Answer:

The gametophyte produces the haploid gametes

Explanation:

Ferns are a group of lower plants that also undergo the ALTERNATION OF GENERATIONS in their reproductive life cycle. The plant consists of the SPOROPHYTE and GAMETOPHYTE. The sporophyte is a diploid plant body that produces the haploid spores via meiosis. These spores are released on the sporangium and grow into a haploid GAMETOPHYTE.

The gametophyte produces the haploid GAMETES i.e. male gametophyte (antheridium) produces sperm while female gametophyte (archegonium) produces eggs, which undergo fertilization to produce a diploid zygote that develops into the sporophyte. The cycle begins again.

Which of the following is true about the taiga biome? a. The taiga biome is the largest biome in the world. b. It is found on five of seven continents. c. The taiga biome has three distinct seasons. d. The temperature in the taiga is rarely ever below freezing.

Answers

Answer:

The Answer is A

Explanation:

B would be incorrect, since it is only found on 3 biomes. C is also incorrect, as there is only 2 distinct seasons. D is false because taiga biomes are very cold, and theres always snowfall there. Leaving the last answer as A.

Taiga biome is a boreal forest with coniferous trees that has major life zones and thick forest zones. It is the largest biome on the globe. Thus, option a is correct.

What is the Taiga biome?

Taiga biome is the snow or the boreal forest that has a cone, pine-bearing trees, and evergreen trees in its region. They are characterized by the long winters and high to moderate precipitation rates.

It covers 11% of the land and hence is the largest biome on the land, located in the northern hemisphere, covering North America, Alaska, and Canada. They are characterized by the presence of coniferous trees with freezing winters, and hot summers along with humid rainy seasons.

Therefore, the taiga biome is the largest biome in the world.

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why did photoelectric make modifications to the Rutherford model necessary.

Answers

the Rutherford model, light of any energy should be able to make electrons leave the atom and be emitted. The energy of the emitted electrons should be related to the intensity of the light.

Gathering data in an experiment is called

Answers

Answer:

Researching

Explanation:

Reseaching is to gather data

The statement that for each force their is an equal and opposite force refers to which law?

Answers

Answer:

The laws of physics.

Explanation:

Formally stated, Newton's third law is: For every action, there is an equal and opposite reaction. The statement means that in every interaction, there is a pair of forces acting on the two interacting objects. The size of the forces on the first object equals the size of the force on the second object.

what is the monomer of a nucleic acid

Answers

Answer:

Nucleotide

Explanation:

It is a nucleotide!

What might happen to biodiversity in area 1 if the new bird species moved into the area

Answers

Answer:

New bird species may alter the ecosystem and modify the trophic chain when they become invasive, leading consequently to the loss of biodiversity

Explanation:

Invasive (also known as alien) species are non-native species capable of spreading into a new area where they have a drastic impact on the ecosystem. An invasive species may cause an important loss of biodiversity and modify the food web in an ecosystem by replacing native species. Examples of invasive bird species include the house sparrow, European starling, cattle egret, rock pigeon, etc. Nonetheless, it is important to highlight that not necessarily new bird species will become invasive (it will depend on their effects on the ecosystem).

Please help
Choose all the answers that apply.

Plants _____.

release oxygen during photosynthesis
use nitrates to make proteins
are eaten by herbivores
cannot use nitrogen directly from the air
need nitrogen for photosynthesis

Answers

Answer: release oxygen during photosynthesis

use nitrates to make proteins

Explanation:

i just googled it homie

Answer:

release oxygen during photosynthesis.

use nitrates to make proteins

cannot use nitrogen directly from the air

Explanation:

Similar cells which work together form???

Answers

Answer:

but why the red tho?

Explanation:

What mental function is common across the animal kingdom?
creativity
memory
language
genetics

Answers

The answer to your question is Memory

Which options describe the structure of a water molecule? Select all that apply. 1. the molecule has an overall straight shape 2. the hydrogen atoms are attached to the oxygen atom at an angle 3. the molecule has an overall bent shape 4. the hydrogen atoms are attached at opposite ends of the oxygen atom

Answers

Answer:3 and 2

Explanation:

For water molecule all options are correct here.

What is the structure of a water molecule ?

Water occupy around 70% of the earth’s surface, it make up about 95% of the living organisms.

Each water molecule is composed  up of one molecule of oxygen and two molecules of hydrogen by forming  a covalent bond .

A strong bond of attraction between nucleus of the oxygen nucleus and  electrons of hydrogen has been seen which form an angle 105° between hydrogen atoms

Due to this asymmetry in shape water has a strong property of strong dipole movement  that is highly polarized molecule with both positive and negative charges.

It is  very cohesive in nature by developing a  strong bonding with itself, and also adhesive in nature.

It shows high boiling point as hydrogen- oxygen bond highly polar and

Hydrogen atoms are present at two corners with a  tetrahedron shaped which gives water a high polarity.

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What is macroevolution?

Answers

Answer:

major evolutionary change

Explanation:

how do humans contribute to natural selection? Help Plz

Answers

we are the top of the food chain, so we hunt a lot. like the way we do the fish in nets, it’s normal now for a fish to be naturally selected to be caught in the fishers’ net. humans contribute by hunting and collecting their own food even if they do it in masses just like how a cheetah catches and eats a gazel.

please tell the different parts of breast with diagram​​

Answers

Answer:

u can take help from pictures

1. The type of organism that possess cell exposed to the environment from all sides is.
O unicellular organism
O multicellular organism
O plants
O animals​

Answers

Answer:

unicellular organism

Explanation:

The type of organism that possesses a cell exposed to the environment from all sides is unicellular organism, option A is correct.

Unicellular organisms, as the name suggests, are composed of a single cell that functions as both the basic unit of life and the interface with the environment. These organisms, including bacteria, protozoa, and some algae, carry out essential processes such as respiration, nutrition, and reproduction within this singular cell.

Due to their simplicity and direct exposure, they can efficiently exchange substances with the surrounding environment from all sides. In contrast, multicellular organism, like plants and animals, possess specialized cell types organized into tissues and organs, limiting direct environmental contact to specific cell surfaces. This fundamental difference in cellular organization is a key characteristic that distinguishes unicellular organisms from their multicellular counterparts, option A is correct.

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The complete question is:

The type of organism that possess cell exposed to the environment from all sides is.

A. unicellular organism

B. multicellular organism

C. plants

D. animals​

The process of converting nitrogen gas to nitrate ions that
plants can absorb is

Answers

The process of converting nitrogen gas to nitrate ions that plants can absorb is
Nitrogen fixation

Where would you expect to find genetic material in a prokaryotic cell?

( WILL MARK BRAINLIEST)


A. In the organelles

B. In the nucleus

C. In the cytoplasm

D. A prokaryotic cell does not genetic material

Answers

Answer:

The answer is Option B the nucleus

Explanation:

Genetic information in prokaryotic cells is carried on a single circular piece of DNA which is attached to the cell membrane and in direct contact with the cytoplasm. There is no enclosing membrane, so there is no true nucleus, but simply a concentration of DNA known as a nucleoid.

and DNA is present in the nucleus. Therefore option B is correct

hope this helped you

please mark as the brainliest (ㆁωㆁ)

Answer:

Its C in the cytoplasm

Explanation:

Prokaryotic cells do not have a nucleus so their DNA floats around in their cytoplasm (This is for anyone that has the exact question, I'm on the globe and this is correct but the more simplified answer)

the importance of fossils to the rock record

Answers

Answer:

The importance of fossils to the rock record is that fossils provide evidence that organisms from the past are not the same as those found today, and demonstrate a progression of evolution

Explanation:

Organisms with a narrow range of temperature tolerance would most likely be found where ?

Answers

Answer:

there is less fluctuation in abiotic factor such as temperature.

Explanation:

Organisms with a narrow range of temperature tolerance would most likely be found where there is less fluctuation of temperature or variation in temperature because the organisms are tolerant to less variation in abiotic factor such as temperature so if the temperature goes very high or low, then the organism is not able to tolerate and die. So we can say that less variation in temperature are the regions where organisms with a narrow range of temperature tolerance can be found.

Glucose is present in blood plasma at a concentration of approximately 80 mg/dL. A typical 70 kg human has approximately 5 L blood, which is 55% plasma. Using the glucose concentration of Sprite that you calculated in the previous question, how many mL of Sprite does a human need to drink to reach a plasma glucose concentration of 80 mg/dL, assuming none is mobilized?

Answers

Answer: 48.93 mL of sprite

Volume of blood in 7 Kg human = 5 L

Percentage of plasma in blood = 55%

Volume of plasma in 5 L blood =  (1 L = 10 dL)

Concentration of glucose in plasma = 80 mg/dL

Amount of glucose present in 27.5 dL : 80 mg /dL × 27.5 dL= 2200 mg

Let the volume of sprite with 2200 mg glucose be x

Concentration of glucose in sprite = 44.96 mg/mL

Explanation:

Myrmecia pilosula was originally described as a single species, however, after closer examination, it was determined to consists of several distinct, closely related, physically similar species. Females have chromosome numbers of 2, 18, 20, 32, 48, 60, 62, and 64. Assume that a cross is made between a female of species (A) with 48 chromosomes and a male species (B) with 10 chromosomes (males are haploid and transmit all their chromosomes to each sperm cell). How many chromosomes would be expected in the somatic cells of the hybrid female offspring?

Answers

Answer:

The correct answer is "34".

Explanation:

The ant Myrmecia pilosula is a special case of sexual reproduction, where the females produce gamete cells with half the chromosomes of the somatic cells and the males are haploids that transmit the whole number of chromosomes in their gametes. Therefore, the somatic cells of the hybrid female offspring that results from the cross of a female ant with 48 chromosomes and a male with 10 chromosomes would have 34 chromosomes. This result from half the number of chromosomes of the female (24) plus the total number of chromosomes of the male (10).

Which cell part contains the cells DNA which controls the cells activities

Answers

Nucleus!! is where the dna is at. Which controls the cells activities through out our body

Which correctly lists three scientists who supported the heliocentric model of the solar system? Aristotle, Ptolemy, Copernicus Copernicus, Ptolemy, Kepler Galileo, Kepler, Aristotle Kepler, Galileo, Copernicus

Answers

The option which correctly lists three scientists who supported the heliocentric model of the solar system is: D. Kepler, Galileo, Copernicus.

A solar system can be defined as a collection of both the inner and outer planets alongside the moon in orbit around the sun. The nine (9) planets of the solar system orbiting around the sun are;

Mercury.Venus.Earth.Mars.Jupiter.Neptune.Venus.Saturn.Pluto.

Heliocentric model of the solar system can be defined as a cosmological model that asserts that the Sun lies at or near a central point while the planetary bodies revolve around it.

Basically, the heliocentric model of the solar system was discovered by Nicolaus Copernicus and supported by Johannes Kepler and Galileo Galilei.

In conclusion, the three scientists who supported the heliocentric model of the solar system are Kepler, Galileo, and Copernicus.

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Answer:

D. Kepler, Galileo, Copernicus.

Explanation:

took the test

In this example:
"A bug repellant is sprayed on one arm the other arm is not sprayed. The number of bug bites is recorded after 2 hours."
What is the dependent variable?

Answers

Answer:

it is the amount of bugs attacking you

Explanation:

the dependent value is what you cannot control, and you can control the bug spray, you cannot control the bugs attacking

Lipid is one of the major classes of biomolecules needed by the body. The body breaks down the lipids that we consume to create and . .

Answers

Answer:

Most lipids we consume in our diet are fats.  lipids break down into diglycerides because of lingual lipase. The fat present in the small intestine stimulates the release of lipase from the pancreas, and bile from the liver enables the breakdown of fats into fatty acids and glycerol

Explanation:

Below the ileocecal valve is a blind pouch called the_________

Answers

Answer:

cecum

Explanation:

If you buy 3kg of pasta for dinner party how many pounds of pasta are you actually preparing for dinner?

Answers

Given :

Mass of pasta buy for dinner party , M = 3 kg .

To Find :

How many pounds of pasta are you actually preparing for dinner .

Solution :

We have to convert 3 kg to pounds .

We know , 1 kg is equal to 2.2 pounds .

So , mass of 3 kg in pounds is :

[tex]M=2.2\times 3\ pounds\\\\M=6.6\ pounds[/tex]

Therefore , 6.6 pounds of pasta is preparing for dinner .

Hence , this is the required solution .

Which of the following is an environmental factor?
A.
Anxiety
B.
Drinking
C.
Smoking
D.
Air or Water pollution

Answers

Answer:D. and maybe C.

Explanation:

Answer:

Air and water pollution

Explanation:

I did the test

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