Different steps of the oxidative decarboxylation of pyruvate by the pyruvate dehydrogenase PDH complex are given. Place these five steps in the correct order. Note that thiamine pyrophosphate, TPP, is sometimes called thiamine diphosphate, TDP.
1. FADH2 is reoxidized to FAD reducing NAD* to NADH.
2. The lipoamide arm of E2 moves to the active site of E1, enabling the transfer of the acetyl group to the lipoamide.
3. Pyruvate reacts with TPP and is decarboxylated forming hydroxyethyl-TPP.
4. The lipoamide arm moves to the active site of E3 where the reduced lipoamide is oxidized by FAD forming the active lipoamide and FADH2.
5. The acetyl lipoamide arm of E2 moves to the active site of E2, where the acetyl group is transferred to CoA, forming acetyl-CoA and the reduced form of lipoamide.

Answers

Answer 1

Answer:

1. Pyruvate reacts with TPP and is decarboxylated forming hydroxyethyl-TPP.

2. The lipoamide arm of E2 moves to the active site of E1, enabling the transfer of the acetyl group to the lipoamide.

3. The acetyl lipoamide arm of E2 moves to the active site of E2, where the acetyl group is transferred to CoA, forming acetyl-CoA and the reduced form of lipoamide.

4. The lipoamide arm moves to the active site of E3 where the reduced lipoamide is oxidized by FAD forming the active lipoamide and FADH2.

5. FADH2 is reoxidized to FAD reducing NAD+ to NADH.

Explanation:

The oxidation of pyruvate to AcetylCoA is catalyzed by the pyruvate dehydrogenase complex. The reaction is an irreversible oxidative decarboxylation process in which the carboxyl group of pyruvate is removed as a molecule of carbon dioxide, CO₂, while the remaining two carbons are attached to a CoASH molecule to form acetylCoA.

The pyruvate dehydrogenase complex contains three enzymes - Pyruvate dehydrogenase known as E₁, dihydrolipoyl transacetylase known as E₂, and dihydrolipoyl dehydrogenase known as E₃. It also requires five coenzymes namely: thiamine pyrophosphate (TPP), flavine adenine dinucleotide (NAD), coenzyme A (CoA-SH), nicotinamide adenine dinucleotide (NAD) and lipoate.

Oxidative decorbyxylation of pyruvate takes place in the pyruvate dehydrogenase complex in five steps:

1. Pyruvate reacts with TPP and is decarboxylated forming hydroxyethyl-TPP.

2. The lipoamide arm of E2 moves to the active site of E1, enabling the transfer of the acetyl group to the lipoamide.

3. The acetyl lipoamide arm of E2 moves to the active site of E2, where the acetyl group is transferred to CoA, forming acetyl-CoA and the reduced form of lipoamide.

4. The lipoamide arm moves to the active site of E3 where the reduced lipoamide is oxidized by FAD forming the active lipoamide and FADH2.

5. FADH2 is reoxidized to FAD reducing NAD+ to NADH.


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Explanation:

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Answers

Answer: Option A) 30 kg

MARK BRAINLEIST PLSS

Answer:

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Answer:

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Answer:

[tex][tex]\purple{\rule{45pt}{7pt}}\purple{\rule{45pt}{999999pt}}[tex][/tex]

Explanation:

[tex][tex]\purple{\rule{45pt}{7pt}}\purple{\rule{45pt}{999999pt}}[tex][/tex]

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Answers

Answer:

Explanation : Reptiles are cold blooded animals, have scales on their body (instead of hair or fur) and are usually egg laying. (certain viper types and boas give birth to live young). So that is what makes animals reptiles.

Reptiles are cold-blooded creatures that often lay eggs and have scales on their bodies rather than hair or fur. (Some types of vipers and boas give birth to live young).

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What are reptiles?

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They comprise of tortoises, turtles, lizards, snakes, and crocodiles.

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Answer:

Explanation:

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Answer:

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Answer:

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Answer:

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What equipment is generally used to make lyophilized medications suitable for administering to the patient

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Answer:

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Answers

To prepare 500 mL of a 2.75 molar solution of NaCl, measure 80.44 g of NaCl, place it in a 500 mL volumetric flask and fill it with water to the mark.

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1 per 2 berarti a.2:3 berarti bagi bagi 1 22. 22 sama dengan 5

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will give brainliest and 100 points to the correct answer

Answers

Answer:

маны

Explanation:

Answer:

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Explanation:

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B. It helps them ask questions that affect as many people as
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C. It helps them make sure a certain question has not been asked
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OD. It helps them determine whether an idea is supported by evidence.
Help

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Answer:

D

Explanation:

It helps determine whether an idea is supported by evidence

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