Dna damage leads to accumulation of ________ p53, which _______ production of a cdk inhibitor to ________ the cell cycle.

Answers

Answer 1

DNA damage leads to accumulation of ____phosphorylated____ p53, which ___increases____ production of a CDK inhibitor to ___halt_____ the cell cycle.

What is phosphorylation?

Phosphorylation is the attachment of phosphate groups to molecules or ions. This process and its reverse dephosphorylation are widely used in biology. Phosphorylation of proteins often activates many enzymes. Protein kinases are activated by phosphorylation, activating a series of events that lead to phosphorylation of various amino acids.

When activated, p53 induces the expression of various gene products, causing either prolonged cell cycle arrest in G1, preventing proliferation of damaged cells, or apoptosis to remove damaged cells from the body .

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Related Questions

heat in the amount of 100 kj is transferred directly from a hot reservoir at 1200 k (th) to a cold reservoir at 600 k. calculate the entropy change of the two reservoirs.

Answers

The net entropy change in two reservoirs is 1/12 kj/K

The second law of thermodynamics states that an increase or decrease in the system's entropy depends on whether heat is accepted into or rejected out of it.

Here, Temperature of source, T- 1200K;

Temperature of  sink, T000K; heat rejected by source-heat accepted by the sink=Q=100kJ;

Decrease in entropy of the source,

ΔS source = Q / T source  = 100/ 1200 = 1/12 kj/K.

Increase in entropy of the sink,

Δ S sink = Q/ T sink = 100/ 600 = 1/6 kj/K.

As it can be seen that Δ S sink > Δ S source, hence the increasing entropy is dominating

So net increase in entropy of the system is given by Δ S system = Δ S sink - Δ S source = 1/12 kj/K.

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Draw the product for the following reaction between an alkyne and one equivalent of hcl.

Answers

To solve such this we must know the concept of addition reaction. The reaction between alkyne and HCl gives addition product. The reaction can be written as

CH[tex]\equiv[/tex]CH +HCl[tex]\rightarrow[/tex]CH[tex]_2[/tex]=CHCl

What is chemical reaction?

Chemical reaction is a process in which two or more than two molecules collide in right orientation and energy to form a new chemical compound. The mass of the overall reaction should be conserved. There are so many types of chemical reaction reaction like combination reaction, double displacement reaction.

Alkyne is electron rich species. The reaction between alkyne and HCl gives addition product. The reaction can be written as

CH[tex]\equiv[/tex]CH +HCl[tex]\rightarrow[/tex]CH[tex]_2[/tex]=CHCl

Therefore, the reaction can be written as

CH[tex]\equiv[/tex]CH +HCl[tex]\rightarrow[/tex]CH[tex]_2[/tex]=CHCl

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Convert the cientific notation to decimal number. Type the correct anwer to the box. 4 x10-power over 5 cm =cm

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The Scientific notation to decimal number , 4 × 10⁻⁵ cm = 0.00004 cm

given data as follows :

scientific notation number = 4 × 10⁻⁵ cm

to convert it in decimal for as :

4 × 10⁻⁵ cm = 4 × 1 / 10⁵ cm

4 × 10⁻⁵ cm = 4 × 1 / 100000 cm

4 × 10⁻⁵ cm  = 4 × 0.00001 cm

4 × 10⁻⁵ cm =  0.00004 cm

so, the conversion of scientific notation to decimal form is given as :  4 × 10⁻⁵ cm = 0.00004 cm. scientific notation is the way of expressing long form to short form and decimal is long form.

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how many valance electrons B (boron) have?

Answers

Answer:

3

Explanation:

nitrogen has an electron configuration of 1s2 2s2 2p3. which electron configuration has a higher electronegativity than nitrogen?

Answers

Answer:

O: 1s2 2s2 2p4

Explanation:

Which variable will you
measure? How will you do this?

Answers

Measuring Variables

Performance measuresAttitudinal measuresBehavioral observationFactual InformationWeb-based data collection

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5. A company is designing a whistle for lifeguards to use. They need to make the frequency between 1,000 and 5,000 Hz. Using the equation f-1/T, determine the
frequency where T-0.00075 seconds.
A. 37.50 Hz
B. 3,750.00 Hz
C. 13,333.33 Hz
D. 1,333.33 Hz

Answers

Answer:

C

Explanation:

which extinguishment method involves foam creating a barrier between the fuel gases and any possible ignition sources?

Answers

The extinguishment method is Smothering

What is smothering?

The technique of smothering involves denying the fire the oxygen it needs to continue burning. Applying fire extinguishing products that block the chemical chain reaction at the molecular level is called interference. Restricting oxygen by keeping air from reaching the fire's center so that the combustion process can lower the amount of oxygen in the enclosed space until the fire extinguishes itself. The foam smothers the flames by covering the fuel surface. The foam covering keeps the fuel surface and the flames/ignition source apart. Foam cools the fuel as well as any nearby metal surfaces. The foam blanket prevents combustible vapors from escaping and mixing with the air. Foam (Class A and B) extinguishes fires in solids and liquids, but not in gases.

The extinguishment method involves foam creating a barrier between the fuel gases and any possible ignition sources is smothering.

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400. ml of no at stp is reacted with 500. ml of o2 at stp. calculate the volume of the reaction mixture at stp after the reaction goes to completion.

Answers

The volume of the reaction mixture at stp after the reaction goes to completion is 700 ml.

What is limiting reagent?

Reagents that are fully consumed during the course of a chemical reaction are known as limiting reagents. They might also be referred to as limiting reactants or agents. The stoichiometry of chemical processes states that a specific number of reactants must be present for the reaction to be completed.

2NO(g) + O2(g) gives  2NO2 (g)

presently, 400 ml of NO = 2 mol of NO2 + 2 mol of NO equals 400 ml of NO2

500 ml of O2 + 2 mol of NO2 + 1 mol of O2

= 1,000 ml NO2

Here, the limiting reagent is NO

as of right now, 400 ml of NO2 = 1 mol of O2 + 2 mol of NO

= 200 ml

500 ml total is divided by that by 200 ml, for a total of 300 ml.

The reaction mixture's total volume is 1000 ml, which is reduced by 300 ml to give 700 ml.

Hence, the volume of the reaction mixture at stp after the reaction goes to completion is 700 ml.

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If the total mass of reactants in a chemical reaction is 20g, what can we say about the total mass of products?.

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If the total mass of reactants in a chemical reaction is 20 g, we can say that the total mass of the products formed in a reaction is 20g.

The law of conservation of mass states that mass cannot be created, nor to be destroyed. It can be converted from one form to the another form. In other words, we can say that the mass of the reactant is equal to the mass of the product. For example, the reaction between 12 g of H₂ and 8 g of O₂ forms 20 g of H₂O. Its balanced reaction is given as

2H₂(8g)+O₂(12g)→2H₂O(20g)

In the above reaction, 8g of hydrogen when reacts with 12 g of oxygen forms 20 g of water as a product. No loss in the mass is observed in the reaction when it is completed.

Therefore, if the total mass of reactants in a chemical reaction is 20 g, we can say that the total mass of the products formed in a reaction is 20g.

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what property is different between the atomic orbitals in a 3p subshell? group of answer choices shape size orientation in space

Answers

The size, energy, and number of nodes of the 2p and 3p orbitals are different from one another. In an atomic orbital, a nodal surface is one where there is no chance of encountering an electron.

The 3d orbital in a multi-electron atom has a higher energy than the 3p orbital. 8 A 3p orbital has a radial node, while a 3d orbital has two. A 3p orbital can hold six electrons, but a 3d orbital can hold ten. Greater than 3p orbitals are 3d orbitals. The highest level of probability for an electron to occur is in an atomic orbital. The route that electrons travel while navigating the restrictions of the shell is referred to as a subshell.

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Explain why cheese curds form when lemon juice is added to milk. Consider the mechanism that keeps colloid particles suspended and how that mechanism could be interrupted.

Answers

The cheese curds are formed due to the coagulation of the protein by acidic lemon juice.

Why does the cheese curds form?

We need to review the fundamental nature of the milk and the lemon juice. In this case, it must occur to us again that milk is made up of a protein and since it is a protein, we know that there is an optimum pH where a protein is able to function quite well. Outside that pH, the protein may not be able to function well.

Again the lemon juice is largely composed of acid since it is of the citrus family hence it contains the citric acid and this would cause the pH of the system to ow tilt towards the acid range.

Having laid these foundations, we can now see that when we do add the lemon juice to the milk the pH of the system is now outside the optimal and the protein in the milk would coagulate thus the cheese curds are formed.

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Write a chemical equation for the acid-base reaction that occurs when p-phenetidine.

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Based on the information provided, it should be noted that an acid-base reaction is a chemical process in which hydrogen ions are transferred between species.

Acid-base reaction: These are the reactions that take place when pure acids and bases are combined.

One of phenetidine's three isomers, P-phenetidine, should be mentioned. Usually, it serves as an intermediary in the synthesis of medicinal medicines.

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How do you find the molar mass of ammonia?.

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The molar mass of ammonia can be find by adding the atomic mass of hydrogen and nitrogen. Molar mass is twice of the atomicity of the compound.

The molar mass is defined as an average of many instances of the compound, which often vary in terms of mass due to the presence of isotopes

We know that ammonia is compound which is made up of nitrogen and hydrogen.

It contains single atom of nitrogen and 3 atoms of hydrogen.

Molecular formula of ammonia is NH₃

So, molar mass of nitrogen =atomic mass of nitrogen +atomic mass of hydrogen

We know that atomic mass of nitrogen is 14 a.m.u  where atomic mass of hydrogen is 1 a.m.u

So, molar mass of nitrogen is =14+3×1=17 a.m.u

Therefore, molar mass of nitrogen is 17 a.m.u

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What is the volume of a cylinder made from * Aluminum with a height of 10mm, a mass of 30g, and a density of 2.7g/cm3?

Answers

The volume of a cylinder is 11.11cm³.

What is volume of a cylinder?

This refers to the amount of space the cylinder contains.  It can be calculated by multiplying its base by its height.

The formula is given by;

volume of a cylinder, vol= πr²h

where,

Pi, π=22/7

the radius of the base of the cylinder, r

Height of the cylinder, h

Note from the question;

Height, H=10mm

mass, m=30g

Density, ρ= 2.7g/cm³

recall,

Density, ρ=Mass/volume

since the mass and the density of the cylinder are given, we can calculate the volume using;

Density, ρ=Mass/volume

ρ=30g/2.7g/cm³

ρ=11.11cm³

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which of the following is false? hydration of alkynes with h3o typically requires a mercury catalyst. acid-catalyzed hydration of terminal alkynes affords anti-markovnikov products. acid-catalyzed hydration of terminal alkynes affords ketone products. in the acid-catalyzed hydration of alkynes, an enol intermediate is formed.

Answers

Hydration of alkynes with h3o typically requires a mercury catalyst is a false statement.

What is hydration of alkynes?

Alkynes are first hydrated by the addition of the first water molecule. But this initial hydration event results in the formation of an enol, an alcohol joined to a vinyl carbon.

Enols instantly go through a particular kind of isomerization process termed tautomerization to create carbonyl groups, such as aldehydes or ketones. With the understanding that aldehydes occur on terminal alkyne carbons, this reaction is referred to as "enol-keto" tautomerization to make things straightforward.

Similar to hydration (adding water) of alkenes, hydration of alkynes necessitates the use of a potent acid, typically sulfuric acid with a mercuric sulfate catalyst.

Therefore,  Hydration of alkynes with h3o typically requires a mercury catalyst is a false statement.

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Consider the first order reaction a → products where 25% of a disappears in 24 seconds. What is the half life of this reaction?.

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The first order reaction A→products, where 25% of A disappears in 24 seconds. The half-life of a reaction is 58 second.

In the given problem, first find out the rate constant for first order reaction. It is calculated as

k=(2.303/t)×log(a/a-x)

Assume that we started with 100% of A. Therefore, a=100

a-x=100-25=75

t=24 seconds

Plug all values in the formula

k=(2.303 second⁻¹/24)×log(100/75)

k=0.09596 second⁻¹×log(1.33)

k=0.09596 second⁻¹×0.12385

k=0.011885 second⁻¹

The half-life for first-order reaction is calculated as

t(1/2)=0.693/k

Plug value of k in the above formula

t(1/2)=0.693 second/0.011885

t(1/2)=58.3088 second

t(1/2)=58 second

Therefore, the half-life of the given reaction in which 25% of A disappears in 24 second is 58 second.

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Chemical reactions and nuclear reactions cause matter to change in different ways. Which two statements describe how matter changes only in a nuclear reaction?.

Answers

Chemical reactions are those that take place between different elements to create bonds through the transfer, sharing, loss, or gain of electrons. While inside the atom's nucleus, nuclear processes take place.

It does not depend on the number of electrons because protons and neutrons are involved. The smallest division into which a chemical reaction can be divided, the elementary reaction has no intermediate products. The majority of reactions that are detected in experiments are built up from several simpler reactions that take place simultaneously or sequentially. chemical reactions mechanism is the term used to describe the real order of the several elementary reactions.

A membrane-bound organelle found in eukaryotic cells is the cell nucleus (plural nuclei; from Latin nucleus or nucleus, meaning kernel or seed). Typically, one nucleus can be found in eukaryotic cells.

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calculate the number of grams of aluminum required to prepare 297.0 g of chromium metal by the first reaction.

Answers

To prepare 297.0g of chromium we need 154.21g of aluminum.

The preparation of chromium using aluminum powder is an exothermic process. It is the reaction where heat is released during the formation of product.

  Therefore, the chemical reaction for the formation of chromium is:

Cr2O3(s) + 2Al(s) -> 2CrO(s) + Al2O3(s)

Here, we can see that 2 moles of aluminum produces 2 moles of chromium.

Hence,

Molar mass of aluminum = 27g

as 2 moles of aluminum is required then 2 x 27 = 54g.

Molar mass of chromium = 54g

As, 2 moles of chromium is obtained then 2 x 54 = 104g.

Therefore, by cross multiplying we get the amount of aluminum required,

mass of aluminum produced = 54 x 297.9/ 104

                                                = 16038/104 = 154,21g.

Therefore, the required amount of aluminum is 154.21g

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an effective hot pack salt can release 5850 j of heat to the surroundings. how many grams of licl are needed to release this amount of heat?

Answers

4.01 grams of Licl are needed to release this amount of heat

What does one gram weigh?

The gram is a unit of mass in the International System of Units (SI) that is equal to one thousandth of a kilogram. It was originally known as the gramme. Gram. This pen cap weighs around one gram. A weight scale like this one may provide a precise mass readout for many different things.

Mass of Licl required to release 5850J of heat to the surroundings.

Let x g Licl required.

Then x g ×∆H = 5850J

x g × 1.46 × 10³ = 5850

x = 5850/ 1.46 × 10³

x = 4.0068

so 4.01g Licl required.

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Calculate the mass of:
a. 0.05 mole of aluminium nitrate
b . 3 moles of carbon tetrachloride

Answers

Aluminum nitrate weighs 106.49811 grams per mole, while carbon tetrachloride weighs 456 grams .1 mole is equal to 1 moles,212.9962388÷ 0.05 = 106.4981g,3 moles carbon tetrachlorid=461.4681g

Why is aluminum employed in explosives?

Aluminum is frequently used because it is easy to produce, compatible with explosives, and creates a very high enthalpy of oxidation. Aluminum is the ideal material for increased explosion applications because of these reactions, which result in a "thermobaric" effect when aluminum reacts with air late in the process.3 moles Carbon Tetrachloride to grams = 461.4681 grams

Why does aluminum make people sick?

Al's toxicity causes oxidative stress, immunologic modifications, genotoxicity, pro-inflammatory effects, peptide denaturation and transformation, enzymatic dysfunction, metabolic dysregulation, amyloidogenesis, transmembrane disruption, metal dyshomeostasis, apoptosis, necro, dysplasia.

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a food has a ph that is higher than the ph of pure water but lower than the ph of an oven cleaning solution. based on this information, the food is a

Answers

A food has a pH that is higher than the pH of pure water but lower than the pH of an oven cleaning solution. Based on this information, the food is an egg white.

A degree of how acidic or simple a substance or solution. pH is measured on a scale of 0 to 14. on this scale, a pH cost of 7 is impartial, which means that it's miles neither acidic nor primary. A pH fee of much less than 7 method it is greater acidic, and a pH price of extra than 7 way it's far extra fundamental.

Excessive pH in a waterbody is considered to have a high pH if pH exceeds nine for extended intervals or with high frequency. Excessive pH is less not unusual than low pH as a candidate cause, due to the fact anthropogenic sources are acidic greater frequently than primary.

There are  techniques for measuring pH: colorimetric techniques the use of indicator solutions or papers, and the extra accurate electrochemical methods the usage of electrodes and a millivoltmeter.

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A chemit crytallize 17. 5g of a olid and iolate 10. 2g a the firt crop and 3. 2g a the econd crop. (a) What i the percent recovery in the firt crop? (b) What i the total percent recovery?

Answers

i. Percentage Recovery in the first crop is: -

We know that,

Percent recovery = (amount of substance isolated at the first crop ÷ amount of substance originally taken) × 100

Thus,

Percent Recovery in the first crop = (10.2/17.5) * 100 = 58.28%

ii.  Total Percentage Recovery is given by: -

Percent recovery = (amount of substance isolated at the first and second crop ÷ amount of substance originally taken) × 100

Thus,

Total Percent Recovery = {(10.2+3.2)/17.5} * 100 = 76.57%

What is Percent Recovery?

The percentage of an original substance that remains after a chemical reaction is finished is calculated using the term "percent recovery." These primarily consist of purifying processes. It also determines how effective they are.

Percent recovery calculation is usually applicable to those reactions in which the identification of the substance to be purified remains the same before and after the reaction.

In organic chemistry, certain elements are purified by conducting the process of recrystallization. A specific element or chemical that needs to be purified is combined with a heated solvent in this method. Later, after cooling the solution, the element or compound precipitates.

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when the pressure of a gas phase reaction at equilibrium decreases, in which direction does the equilibrium shift?

Answers

As pressure rises, the equilibrium will move to the side of the reaction where there are less moles of gas. When the pressure drops, the equilibrium will move to the side of the process where there are more gas molecules.

Which way does the equilibrium move when the reaction pressure at the equilibrium decreases?

According to Le Chatelier's principle, a pressure change will cause an equilibrium to shift to the reaction's side that has the fewest moles of gas, while a pressure change will cause it to shift to the reaction's side that has the most moles of gas.

Pressure reduction shifts the equilibrium to the side with the majority of molecules. This lessens the effects of the change because as the number of molecules increases, so does the pressure.

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automotive air bags inflate when sodium azide decomposes explosively to its constituent elements: how many moles of n2 are produced by the decomposition of 2.88 mol of sodium azide?

Answers

4.32 moles of N2 are produced by the decomposition of 2.88 mole of sodium azide.

Equation:

2 NaN3(s) ⇒ 2 Na(s) + 3 N2(g)

According to the above equation, sodium azide has the chemical formula NaN3, while nitrogen gas has the formula N2.

Therefore, if on decomposition

3 moles of N2 is created by 2 moles of NaN3

Z moles of N2 is created by 2.88 mole of NaN3

To get the value of Z, cross multiply

Z x 2 moles = 3 moles x 2.88 moles

2 moles x Z = 8.64 moles²

Divide both sides by 2 moles

2 moles x  Z/2 moles = 8.64 moles²/2 moles

Z = 4.32 moles

Thus, 4.32 moles of N2 are produced by the decomposition of 2.88 mole of sodium azide.

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which is NOT a result of water surface tension

1. water forming spherical drops on all freshly waxed surfaced
2.an insect floating on the surface of water
3. water raising up into a thin glass tube
4. ice floating in liquid water

Answers

2.an insect floating on the surface of water

Ice floating in liquid water is not a result of water surface tension, This is due to ice's lower density than liquid water, a result of its unique hydrogen bonding arrangement.

Option (4) is correct.

Surface tension is a property of liquids, including water, caused by the cohesive forces between their molecules. It results in the formation of a "skin" on the liquid's surface, which gives rise to several observable phenomena.

1. Water forming spherical drops on freshly waxed surfaces: This happens because of the cohesive forces between water molecules, which cause the liquid to minimize its surface area and form spherical shapes.

2. An insect floating on the surface of water: Surface tension allows insects like water striders to walk on water. The cohesive forces hold the water's surface together, enabling the insect to stay afloat.

3. Water raising up into a thin glass tube (capillary action): Surface tension, along with adhesive forces between water and glass, allows water to rise against gravity in thin tubes.

4. Ice floating in liquid water: This is an exception to the usual behavior of substances. Ice is less dense than liquid water, so it floats on the surface due to its unique hydrogen bonding arrangement.

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how does the diagram illustrate the relationship between respiration and photosynthesis

Answers

During photosynthesis, plants take in carbon dioxide from the atmosphere and exhale oxygen. Then, during breathing, animals take this oxygen in and exhale carbon dioxide.

What is the carbon cycle explain?

The carbon cycle is the best way that civilization has found to recycle carbon atoms, which continually flow from the atmosphere into living organisms on Earth and back again. While the ocean, the air, and living things all contain some carbon, rocks and sediments are where the majority of it is preserved.

Why is the carbon cycle important?

The carbon cycle is essential to life on Earth. Because nature tends to keep carbon levels in balance, the carbon content that is naturally produced by reservoirs is similar to the amount that is typically absorbed by reservoirs. By maintaining this carbon balance, the planet can sustain life indefinitely.

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how many of the identified elements are present in each compound:
option choices are 1,2,3,4,10,12,16 they can be used multiple times

Answers

The numbers of the compounds (1 - 9 as shown) and the number of atoms of each element are shown below;

1) One Al atom

2) Three oxygen atoms

3) three hydrogen atoms

4) 1 magnesium atom

5) 2 carbon atoms

6) 2 nitrogen atoms

7) 3 nitrogen atoms

8) 12 hydrogen atoms

9) one phosphorus atom

What is a compound?

A compound is composed of elements. The elements that make up the compound must be bonded by means of a chemical bond. The bond could be an ionic bond, a covalent bond or a metallic bond. The ionic bond is more found among metals and non metals. The covalent bond is found among two nonmetals while the metallic bond is found between two metals.

Now we know that there is a given number of the atoms of each element that we can find in a compound and this varies from one element to another. We can know the number of atoms that can be found in each of the elements if we can be able to look at the chemical formula of the compounds.

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Exercise 10.7 An American newscast states that the barometer reads 29.6 in. Hg. Express the atmospheric pressure in each of the following units. kPa Express your answer with the appropriate units. TINA RO ? P= Value Units Submit Request Answer Part B torr Express your answer with the appropriate units. Value Units

Answers

Hg = 101 kPa. A "dropping" barometer, according to meteorologists, signals an impending storm. Considering a 27.5 inch barometric pressure

Two things concerning a barometer:

Barometer, a tool for calculating atmospheric pressure. Due to the fact that air pressure changes with elevation above or below sea level, a barometer can also be used to measure height.

Who and when made the barometer?

Even though Torricelli is credited with creating the first device to measure atmospheric pressure (the barometer), his discovery was somewhat accidental. In order to create a vacuum, his main goal was to fill a 4-foot-long, narrow glass tube with mercury and invert it into a dish in 1643.

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1. A neutral atom has a mass number of 128 and an atomic number of 52. Use this information to fill in the table below.
Question Answer
How many protons are in this atom? How do you know?

How many electrons does the atom have? How do you know?

Calculate the number of neutrons – show your work.

If this atom becomes an ion with a +4 charge, how many electrons would the ion have?
This atom has an isotope with one extra neutron – what is its mass number?

Answers

1) p=52

2)p=e=52

52-4=48

128

Other Questions
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