HIF1α is a key player in angiogenesis. VHL is a protein required for the degradation of HIF1α in the normal oxygen level. Loss-of-function mutations in the VHL gene have been found to promote tumor growth. Please explain why these mutations can promote tumor growth?

Answers

Answer 1

Answer:

Explanation:

The VHL gene is a tumour suppressor gene that regulates cell growth and cell death. This gene is also located on chromosome 3. It functions to prevent rapid proliferation of cells. For a person to develop tumor both copies of the gene must be mistake or altered allowing for a loss of function that prevents its from causing degradation of HIF1α in the normal oxygen level as its it normal function. This then allows for the survival of HIF1α that promotes amgiogenesis promoting tumor development.


Related Questions

So how you liking Earth? Are you loving your existence ?​

Answers

No, not really. I'm only here because I need points so ask a question for school.

Answer:

CHING CHONG CHINKY WONG

Explanation:

define the ratio of sperm to egg?

Answers

Answer:

1,2 × 10⁹ : 1

Explanation:

In fact, the average male will produce roughly 525 billion sperm cells over a lifetime and shed at least one billion of them per month. A healthy adult male can release between 40 million and 1.2 billion sperm cells in a single ejaculation.

Explanation:

Therefore, a standard sperm to egg ratio of 1 × 105 sperm per egg is recommended for fertilization in Atlantic cod. At the 1 × 103:1, 5 × 103:1, and 1 × 104:1 sperm to egg ratios maximum fertilization occurred after 30 min sperm to egg contact time.

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Who first suggested the theory of evolution by natural selection?
O A. Charles Darwin
B. Wilhelm Weinberg
C. Gregor Mendel
D. Thomas Malthus

Answers

Charles Darwin!
Darwin and a scientist contemporary of his, Alfred Russel Wallace, proposed that evolution occurs because of a phenomenon called natural selection.

Charles Darwin first suggested the theory of evolution by natural selection.  Therefore, option (A) is correct.

Who was Charles Darwin?

Darwin was a British naturalist who conducted extensive research and observation during his travels around the world, and his work culminated in the publication of "On the Origin of Species" in 1859. In this seminal work, Darwin proposed that species evolve over time through a process he called natural selection, which involves the differential survival and reproduction of individuals with advantageous traits.

This theory challenged the prevailing view of species as unchanging, fixed entities and revolutionized the field of biology. While Darwin was not the first to propose the idea of evolution, his theory of natural selection provided a mechanism to explain how it occurs and remains one of the most important and influential ideas in the history of science.

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Can seaweed help curb global warming?

Answers

Answer:

no.......................................

Answer:

yessss

Explanation:

hahhahhaha

zoom in to see

which of these forms when moves in the directions shown by the arrows in the diagram

Answers

Answer:

A. Mountain breeze

Pls give 5 stars and thanks!

Answer:

a

Explanation:

Which type of selection leads to increased phenotypic and genetic variation? directional selection disruptive selection stabilizing selection species selection

Answers

Answer:

diruptive selection/ diversifying selection

Explanation:

disruptive selection often leads to more variations in species

The circumstance that concludes whether the organism will be able to accommodate and endure in the changed conditions is called selection.

The correct answer is:

Option B. Disruptive selection.

This can be explained by:

Disruptive or diversifying adaptation occurs when there is a change in population genetics in which the traits are valued over intermediates.

This type of assortment supports either the dominant or the recessive trait but do not favour intermediates.

For example, in selection between tall, short or intermediate organisms the tall and short will be selected over the medium heightened organism.

Therefore, disruptive selection will lead to increased phenotypic and genetic variation.

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As a muscle I am responsible for regulating leaving teh body

Answers

Answer:

The digestive system is in charge of squeezing energy and nutrients out of all that ... Anus: The place where solid waste exits the body.

How are glaciers, glaciation and human activities relate to climate change or global warming

Answers

Answer:

The Production of C02 Co2 is an greenhouse gas and will go up into the atmosphere to heat it if the atmosphere is gaining to Much C02 it will heat up therefore Glaciers Will melt under the increasing heat a

What most directly causes hypertension?

Answers

Answer:

hypertension is caused by stress and salt intake

The most common causes of hypertension include smoking, obesity or being overweight, diabetes, having a sedentary lifestyle, lack of physical activity, high salt or alcohol intake levels, insufficient consumption of calcium, potassium or magnesium, a deficiency in vitamin D, stress, aging, chronic kidney disease

state two proteins in blood which are responsible for determine the blood group of a person​

Answers

Answer:

DNA

Explanation:

A person DNA determines the type of enzymes they have, and, therefore, the type of sugar antigens that end up on their red blood cells . In contrast , the antigens of the Rh blood group are proteins . A person DNA holds the information for producing the proteins antigens

For children who do not have galactosemia, what are their possible genotypes for this trait?

a pedigree chart for the inherited genetic condition galactosemia

heterozygous
homozygous dominant
homozygous recessive
no inheritance for this trait

Answers

Answer:

The correct answers are "heterozygous", and "homozygous dominant".

Explanation:

Galactosemia is a condition where people are not able to process the sugar galactose. People with this condition have one gene mutated, which does not allow the proper synthesis of the enzyme that breaks down galactose. Galactosemia is inherited as an autosomal recessive genetic condition, therefore, only children that are homozygous recessive develop the condition. Children that are heterozygous or homozygous dominant, will not develop galactosemia.

Answer:

its heterozygous and homozygous dominant

Explanation:

А (blank)
is a chemical substance that organisms require to live.​

Answers

Answer:

Nutrient

Explanation:

Nutrients are compounds in foods which are essential to life and health of living organisms, providing them with energy. They are the building blocks for repair and growth and substances necessary to regulate chemical processes. There are six major nutrients:

Carbohydrates,Lipids (fats),Proteins,Vitamins,Minerals,Water.

why is nectar important for insects?

Answers

Answer:

Nectar is important for insects because.. Nectar is an ecologically important item, the sugar source for honey. It is also useful in agriculture and horticulture because the adult stages of some predatory insects feed on nectar. For example, the social wasp species Apoica flavissima relies on nectar as a primary food source. In turn, these wasps then hunt agricultural pest insects as food for their young.

Explain the central dogma of molecular biology. please don't define it or state what it says.

Answers

Answer:

The central dogma of molecular biology is an explanation of the flow of genetic information within a biological system. it is often stated as "DNA makes RNA, and RNA makes protein", although this is not its original meaning.This states that once "information" has passed into protein it cannot get out again.

Explanation:

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Which is required for sexual reproduction? 1.mitosis 2.binary fission 3.diploid cell production 4.meiosis

Answers

Answer:

4. Meiosis

Explanation:

Mitosis creates cells for growth and repair, not for sexual reproduction. Binary fission is a form of asexual reproduction, not sexual reproduction. Diploid cell production is mitosis (mitosis creates diploid cells, or cells with a full set of chromosomes)

Meiosis is the correct answer. Meiosis creates gametes or sex cells that are necessary for sexual reproduction. Through this cell division process, 4 gametes are produced. The cells that are produces are haploid, which means they only have half of a full set of chromosomes. The cells are haploid because, during fertilization, a sperm (male sex cell) and egg (female sex cell) fuse. The result is a diploid zygote with half of the genetic information from the father and the other half from the mother.

The correct answer is 4. Meiosis.

Answer:

its D. Meiosis

Contrapposto is defined as:
O a photographic print process using gum Arabic.
an asymmetrical arrangement of the human figure.
a German term to denote devotional images used to aid prayer.
diagonal lines the recede into fictive space.

Answers

Answer:

an asymmetrical arrangement of the human figure.

Explanation:

Contrapposto is an Italian term and it is use in visual art to describe

an asymmetrical arrangement of the human figure in which the line of the arms and shoulders contrasts with and balances the line of the hips and legs. It was an important sculptural development,it unveiling marks the first time in Western art that the human body is used to expression of relaxed physiological disposition.

Please help! 100 points!

What are some ways that the nitrogen cycle overlaps with or influences the oxygen and carbon cycles?


Are any of these interactions between the cycles positive?


Are any negative?


What about when the nitrogen cycle is thrown off balance by the Haber-Bosch process and others like it?


How can that influence the oxygen and carbon cycles?


Are there other cycles involved that have not been mentioned in this question?


What does this discussion suggest about the nature of the Earth as one large system?

Answers

Answer:

1. Nitrification occurs when soil microbes convert ammonium into nitrate. Much of the overlap between the carbon cycle and the nitrogen cycle occurs in the soil, in processes conducted by soil microbes. Microbes break down nutrients, build new compounds for their own growth, and eventually die.

The second question im not sure sorry- the positive and negative one ;(

3. Many human activities have a significant impact on the nitrogen cycle. Burning fossil fuels, application of nitrogen-based fertilizers, and other activities can dramatically increase the amount of biologically available nitrogen in an ecosystem. As nitrogen makes up 78% of the atmosphere, there is no shortage of it – it just isn't in a form plants and animals can use.

4. Carbon makes its way through living things as carbon-based compounds, like energy molecules, fats and proteins, eventually cycling its way back into the atmosphere. Nitrogen is mainly found in the atmosphere as well and enters the ecosystems as nutrients for plants. Water, nitrogen and carbon cycles. Carbon moves from the atmosphere and back via animals and plants. Nitrogen moves from the atmosphere and back via organisms. Water moves on, above, or below the surface of the Earth.

5. Carbon cycle, Nitrogen cycle, Nutrient cycle, Oxygen cycle, Phosphorus cycle, Sulfur cycle, Rock cycle, Water cycle.

6. Wind, water, and ice erode and shape the land. Volcanic activity and earthquakes alter the landscape in a dramatic and often violent manner. And on a much longer timescale, the movement of earth's plates slowly reconfigures oceans and continents. Each one of these processes plays a role in the Arctic and Antarctica.

Humans impact the physical environment in many ways: overpopulation, pollution, burning fossil fuels, and deforestation. Changes like these have triggered climate change, soil erosion, poor air quality, and undrinkable water. Earth's surface is the only habitat available to the human race. Understanding the processes by which that habitat has been created and continually altered is important to determine the causes of environmental degradation.

Which feature is created by deposition from rivers

Answers

Answer:

Explanation:

The answer is meanders

Hope this helps

Plz mark it as brainliest!!!!!!!!!

Answer:

The person is right

A _____ model places Earth at the center of the solar system, with the Sun and planets revolving around Earth. A. scale B. geocentric C. heliocentric

Answers

Answer:

B. Geocentric

Explanation:

Geo means Earth, and centric means "in the center". So a geocentric model of the solar system would mean the Earth were at the center of the solar system, with the Sun and planets revolving around the Earth.

Answer:

geocentric model

In astronomy, the geocentric model (also known as geocentrism, often exemplified specifically by the Ptolemaic system) is a superseded description of the Universe with Earth at the center. Under the geocentric model, the Sun, Moon, stars, and planets all orbited Earth.

Hope this helps!

which statement best describes how genes are able to produce a organism's traits?

Answers

Answer: Genes come in pairs which are passed down by the parents'. Both parents pass on one copy of their genes to create a gene for the child; this will later create a trait.

The stems of horsetails contain:

A. spores
B. utensils
C. silica

Answers

The answer is C) Silica

The Serengeti region of Africa contains a population of cheetahs and a population of lions. Studies have shown that the cheetah population has very low genetic diversity, while the genetic diversity of the lion population is quite high. The cheetah population is also much smaller than the lion population. Both populations are vulnerable to infection with a particular virus that can be fatal in both species. What is the most likely outcome if both populations are infected with this virus?

A.
The cheetah population is more likely to survive because there are fewer individuals for the virus to attack.
B.
The lion population is more likely to survive because larger populations are immune to viruses.
C.
The cheetah population is more likely to survive because lower genetic diversity increases immunity to viruses.
D.
The lion population is more likely to survive because it is more likely to have individuals with traits to combat the virus.

Answers

Answer:

D. The lion population is more likely to survive because it is more likely to have individuals with traits to combat the virus.

Explanation:

Since lions have greater genetic diversity it is likely that there's one or two lions that have a trait to resist or kill the virus thus won't be infected, whereas, since cheetah's have low genetic diversity and low population size it is likely that they have little to no chance to surviving this virus attack since the genetic makeup is similar among the members of cheetah species.

Answer:

d

Explanation:

plato

The extract of which gymnosperm seed is used to help improve memory?

Answers

Answer:

Ginkgo

Explanation:

Ginkgo improves memory and enhance circulation and metabolism in the brain.

Answer:

ginkgo

Explanation:

ginkgo seed is used to help improve memory

Which statements accurately describe carbon? Check all that apply.
Carbon has fourteen valence electrons.
Carbon forms millions of known compounds.
Carbon can only form single covalent bonds.
Carbon bonds with oxygen, nitrogen, sulfur, and phosphorus.
O Carbon bonds with halogens such as chlorine and iodine.​

Answers

Answer:

B, D, E

Explanation:

Just did it on edge 2020

Carbon is the element with the atomic number six. It can form millions of known compounds and can bond with nitrogen, phosphorus, oxygen, and sulfur, as well as halogens. Thus, options B, D, and E are correct.

What are carbons?

Carbon is studied under carbon chemistry and is the major part of organic chemistry. It is an element in the periodic table with the atomic number six and a mass of 12 amu.

The carbon is known to be unreactive and can form a covalent bond by sharing its four valence electron. It can form bonds with oxygen, sulfur, nitrogen, and phosphorus.

It can also bond with halogens like chlorine and iodine to form carbon tetrachloride by sharing its valence electron in its outer shell to form the compounds.

Therefore, options B, D, and E. carbons links with various elements through covalent bonds.

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If there are 3 ft in 1 yd, which of the following are possible conversion factors for feet and yards? Check all that apply

Answers

Can u pls attach the answers so I can help? :))

Answer: 1yd over 3ft and 3ft over 1yd ( a and d)

Explanation: ….

During the process of mountain building, earthquakes sometimes occur along continental-continental convergent boundaries. Which statement best describes the motion of the plates along these boundaries that causes the earthquakes?

Answers

Answer:

Although you have not put the answer options, the movement of the plates in the situation shown above occurs with the approach of their continental plates that collide and bend due to the impact.

Explanation:

The converging movement of the plates indicates that two plates are moving towards each other until they collide. When these two plates are continental, the movement is called continental-continental convergent.

As the two continental plates have the same density, the impact between the two causes them to bend and not sink into each other.

Answer:

D) the plates smash together with no subduction

Explanation:

Got it right!

What does an unstable isotope give off that a stable isotope does not?

Answers

Answer:

An unstable isotope emits some kind of radiation, that is it is radioactive. A stable isotope is one that does not emit radiation,

Explanation:

Many elements have one or more isotopes that are radioactive. These isotopes are called radioisotopes. Their nuclei are unstable, so they break down, or decay, and emit radiation. The nucleus may be unstable because it has too many protons or an unstable ratio of protons to neutrons.

2. In the example of the white and brown mice, vultures will prey on both colors of mice. However, in
the desert environment, the brown mice are better able to hide from their predators and have an
advantageous trait. What will happen to the color of mice over time?

Answers

Answer:

The brown color of mice would become more common in the population of the mice in the desert overtime

Explanation:

In the mice population, since the environment favors the individuals with brown fur color over individuals with white fur color, as it makes them better able to escape from predatory vultures, white mice gets eaten more often. With time, the population of white mice reduces while that of brown mice increases.

Overtime, brown mice leaves more offspring with its trait compared to white mice. As a result of this, the color mice that would be more common in the desert environment would be mainly brown colored mice, while white mice would be few.

PLSSS HELPPP MEEE WITH THIS QUESTIONNNNN NO GUESSING PLSSSS
Which process is shown in the plant cell below?

A= cell growth
B= cell reproduction
C= metamorphosis
D= photosynthesis

Answers

the answer is B = cell reproduction

The given process shown in the image is cell reproduction. Cell reproduction takes place by mitosis and meiosis.

What is cell reproduction?

Mitosis and meiosis are the two distinct processes of cell division. When people talk about "cell division," they typically mean mitosis, which is the process of creating new cells for the body. The cell division process known as meiosis is what produces egg and sperm cells.

A vital process for life is mitosis. A cell divides into two identical daughter cells after duplicating all of its components, including its chromosomes. Due to the importance of this procedure, specific genes carefully regulate each phase of mitosis.

Meiosis, the second sort of cell division, makes sure that each generation of people has the same number of chromosomes.

Therefore, The given process shown in the image is cell reproduction. Cell reproduction takes place by mitosis and meiosis.

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The gluten-free diet was originally intended for people with celiac disease, but it's now become a new fad diet for the general population. Many people state that gluten-free diets are beneficial for people who aren't sensitive to gluten, while others suggest that there's no benefit. Use credible resources to evaluate the argument yourself. Do you think there's sufficient scientific evidence to support the use of a gluten-free diet in people who aren't sensitive to gluten? Provide evidence that supports your argument.

Answers

Answer:

hey love! so i actually have celiac so i know a lot about this haha! hope this helps!!

Following a gluten-free diet in the absence of celiac disease may be detrimental to health. Nutritional deficiences: Avoiding foods that contain gluten can lead to deficiencies in essential nutrients, including iron, calcium, fiber, folate, thiamin, riboflavin, and niacin.

Explanation:

In recent years, the gluten-free diet has become more of a fad than a medical necessity. ... The study concluded that more gluten consumption is associated with a lower risk of heart disease, suggesting that those who do not suffer from celiac disease or non-celiac gluten/wheat sensitivity should not avoid gluten. Though many health professionals suggest otherwise, it's safe to follow a gluten-free diet — even for people who don't necessarily need to do so. Cutting out wheat and other gluten-containing grains or products will not cause adverse health effects — as long as these products are replaced with nutritious foods.

Answer:

Explanation:

There’s no benefit to a gluten-free diet for people who aren’t sensitive to gluten. Many websites state benefits of a gluten-free diet. These benefits range from weight loss to improved heart health. None of these sites backed up their claims with scientific research. More credible sites consistently state that there’s no scientific research to back up these claims. Right now, there’s no evidence that supports the benefits of a gluten-free diet in people who aren’t sensitive to gluten.

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