Molecules move into and out of the cell by active and passive transport every second. active transport require ATP energy whereas passive transport does not require energy.
Both passive diffusion and active transport are fundamentally different ways that solutes move across membranes. The solution reaches equilibrium across the membrane as a result of passive diffusion, which only uses the electrochemical (concentration) gradient of the solute as an energy source. Passive diffusion can take two forms: simple passive diffusion, in which the solute simply dissolves into and diffuses through the lipid bilayer, and facilitated passive diffusion, in which the solute crosses the membrane at specific locations where diffusion is aided by solute-specific facilitators or carriers. A nonequilibrium, net buildup (uptake) of the solute is produced by active transport, which demands additional energy, frequently in the form of ATP, and occurs on one side of the membrane.
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