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Answer 1

B is the gene for brown hair and b is the gene for red hair. In the Punnett square below, the gene that belongs to the empty box is bb.

According to the Punnett square, offsprings from these two parents have a 50% chance of inheriting one B allele and one b allele. For the B gene, the Individuals that inherit these two alleles are heterozygous.

Inheriting Bb confers the phenotype is brown hair. Whereas, inheriting bb confers the phenotype is red hair.

For predicting the possible allele combination and their frequencies for a particular cross the Punnett square is used.

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Describe the absorbption of glucose when its concentration is high in the blood than in the ileum.​

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Answer:

When the concentration of glucose is high in the blood than it is in the ileum, the glucose will be absorbed by facilitated diffusion. Facilitated diffusion is a process in which a carrier molecule binds to the glucose molecule, allowing it to move through the cell membrane into the ileum. Once the glucose molecule is inside the ileum, it can be taken up by the cells to be used for energy. This process ensures that the glucose concentrations in both the blood and the ileum remain in equilibrium.

Explanation:

true/false. A married couple decide they wish to start a family and they really want to have a baby girl. Because of financial considerations, they decide they will have children until they have a girl or a total of 3 children. If the probability of having a boy or girl is equally likely, determine the expected number of boys.

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Answer:

you said t/f but then you asked a question on the end? I’ll do my best tho lol

If it’s true of false, boys are more common than girls.
I guess that could also answer the question. Boys are more commonly birthed than girls, although I feel as if lots of times girls are first born, or maybe that’s just the people around me. Hope it helped :))

Explanation: what I’ve learned in life and from charts lol

what is the main difference between arteries and veins?

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Arteries carry oxygenated blood to all body parts, whereas veins carry the deoxygenated blood to the heart.

What are the arteries' and veins' three main distinctions?

Blood is carried by veins toward the heart and by arteries away from the heart. Veins transport deoxygenated blood, and arteries carry both, with the exception of pulmonary blood vessels. Muscle tissue lines the thick walls of arteries. Veins use valves and have thinner walls to keep your blood flowing.

Do veins carry blood with oxygen?

The three primary categories of blood vessels.The red blood vessels, or arteries, transport oxygen and nutrients from your heart to your body's tissues. The veins (blue) return the heart's oxygen-deficient blood.

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which class of echinoderm is known for its serpentine arms that are easily distinguished from the central disc. a detritus feeder that uses its tube feet to sense the environment

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Class of echinoderm known for its serpentine arms that are easily distinguished from the central disc is : Ophiuroidea.

What is Ophiuroidea?

Because of the fragility of their snake-like arms, Ophiuroidea are also known as brittle stars.

Brittle stars are in the class Ophiuroidea, which also includes basket stars, while sea stars are in the class Asteroidea. Look at their bodies to start differentiating the two. Particularly when examining the location where the arms join to the body's core, their basic structural differences are apparent.

Any of the 2,100 surviving species of marine invertebrates that make up the subclass Ophiuroidea are known as brittle stars, sometimes known as snake stars (phylum Echinodermata).

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What is natural selection and its types?

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Answer:

Image result for What is natural selection and its types?

Directional selection, stabilizing selection and disruptive selection are three types of natural selection. They are also examples of adaptive evolution. Natural selection is the mechanism of evolution which favors organisms that are better adapted to their environments.

which modified root is this
pliz guys help me

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The modified root in the diagram is a taproot.

How many modifications of roots are there?

The main forms of root modifications are tap roots and adventitious roots. Some plants' roots change shape and become modified in order to absorb and transport water and minerals from the soil to various parts of the plant. They have also been modified for support, food storage, and breathing.

The root modifications serve two purposes: physiological and mechanical. A taproot is the main root of a primary root system that grows vertically downward. Most dicotyledonous plants, such as dandelions, produce taproots, and some, such as carrot and beet edible roots, are specialized for food storage. carrot.

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A goat can produce milk containing the same polymers present in the silk produced by spiders when particular genes from a spider are inserted into the goat’s genome. Which of the following reasons describes why this is possible?
answer choices
goats and spiders share a common ancestor and thus produce similar protein excretions
goats retain all the genes that were found in ancestral species and will express these proteins when activated by gene insertion
the proteins in goats milk and spiders silk have the same amino acid sequence
the universal nature of the genetic code allows for the production of identical proteins from different organisms as long as the DNA sequence is identical

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According to the statement, about why goats can produce milk, which contains the same polymers present in the silk produced by spiders, it is because, goats retain all the genes that were found in ancestral species and will express these proteins when activated by gene insertion. The correct answer is B.

This means that when a gene from a spider is inserted into the goat’s genome, the goat will express the corresponding proteins in its milk. Since the proteins in spiders’ silk and goats’ milk have the same amino acid sequence, the goat’s milk will contain the same polymers as spiders’ silk.

Goats have been used in biotechnology research for many years, and researchers have found that they can successfully express proteins from other species in their milk. This is made possible by introducing a gene from the other species into the goat’s genome, allowing the goat to produce the corresponding protein in its milk. This technique has been used to produce spider silk proteins in goats’ milk, which is composed of a similar set of amino acid sequences as the silk produced by spiders.

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Three of the four answers listed below concern cells with two chromosome sets. Select the exception. a. zygote b. somatic cells c. gamete d. diploid

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Answer:

Somatic cells are the exception among the options given. They typically have a single set of chromosomes, also known as being haploid.

Explanation:

If wild-type GALT is designated as G and the recessive allele is designated as g, determine the genotypes of the following individuals. Drag a genotype to each individual in the pedigree. Labels may be used more than once or not at all.

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A genotype of each individual in the pedigree:

Jean → ggPatricia → GgLes → GgJohn → ggMary → G_

Pedigree notes the picture.

Galactosemia is a condition that affects how the body digests galactose. The most common form of galactosemia type I, is the most severe and is caused by mutations in the GALT gene, which encodes an enzyme that processes galactose.

Galactosemia is inherited in an autosomal recessive manner. Imagine that Mary has a normal metabolism but her brother John has galactosemia. Mary and John's parents, Patricia and Les, did not suffer, although their grandmother Jean did.

A recessive gene is a segment of DNA encoding a specific trait that is expressed only when both chromosomes carry versions of the same DNA strand.

If the DNA strand is matched to another version of a different DNA segment, the other DNA is more likely to be expressed than the other DNA, it is called the dominant gene.

The G allele is dominant and the g allele is recessive. If the Gg genotype of Mary and John's parents is not expressed in galactosemia, they are just carriers, then their son will have John suffering from galactosemia. Because the g allele is linked to the X chromosome.

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Which situation would most likely lead to allopatric speciation? a. Flood causes the formation of a new lake. b. A storm causes several large trees to fall down. c. A mutation causes a new trait to develop. d. An injury causes an organism to seek out a new food source.

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(C) flood causes the formation of a new lake would most likely lead to allopatric speciation.

Allopatric speciation occurs when a species separates into two separate groups which are insulated from one another. A physical hedge, similar to a mountain range or a raceway, makes it insolvable for them to breed with one another.

Allopatric speciation due to geographic separation The northern spotted owl and the Mexican spotted owl inhabit geographically separate locales with different climates and ecosystems. The owl is an illustration of allopatric speciation.

Allopatric speciation, also known as geographic speciation, is speciation that occurs when natural populations of the same species come insulated due to geographical changes similar to mountain structure or social changes similar to emigration.

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Environmental and cultural factors don't affect someone's level of learning or academic performance that much.T/F

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Environmental and cultural factors don't affect someone's level of learning or academic performance that much. It is False.

Conflict between diverse cultural groups can be sparked by cultural norms. Culture has an impact on the context in which an action is appropriate. The social environment affects learning by offering children a language- and experience-rich environment that fosters cognitive growth and by constantly rewarding them for learning.

These cultural elements could have an impact:

socialization of children

Sociocultural proximity

Environmental modification

Biology-related effects

One of the elements is language.

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Which of the following correctly describes the chapparal biome?
O Cold temperatures with high rainfall
O Equatorial biome with high rainfall
O Temperate biome with minimal rainfall
O Warm temperatures with moderate rainfall

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The  following correctly describes the chaparral biome: warm temperatures with moderate rainfall, which is the last point, and this type of biome is generally found in Mediterranean climates.

What is the significance of the chaparral biome?

There are various types of biomes found all over the world, and the chaparral biome is one of them and it is seen in warm climates like the Mediterranean, such as California, chile areas and has dense shrubs and small trees.

Hence, the following correctly describes the chaparral biome: warm temperatures with moderate rainfall, which is the last point, and this type of biome is generally found in Mediterranean climates.

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which american thinker is least associated with study using scientific methods? select one: a. henry james b. charles s. peirce c. charles darwin d. john dewey e. edward a. ross

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Answer:

E. Edward A. Ross. Edward A. Ross is an American sociologist who is least associated with the study of scientific methods. He is best known for his criticism of immigration, which he believed would lead to the deterioration of American society. He was also a strong advocate of Social Darwinism, which is a pseudoscientific belief in the superiority of certain races.

scientists think that all of life on earth originated from which type of organism? responses multicell animals multicell animals stromatolites stromatolites single-cell prokaryotes single-cell prokaryotes single-cell eukaryotes

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Answer:

Single-cell prokaryotes. Scientists think that all of life on earth originated from single-cell prokaryotes, which are the simplest form of life. These single-celled organisms are believed to have evolved over billions of years, eventually giving rise to more complex multicellular organisms. Stromatolites are the oldest known form of life on earth, and are formed by the growth of ancient single-celled prokaryotes. Single-cell eukaryotes are more complex than prokaryotes, and are believed to have evolved from them.

assertion: plasma membrane is semipermeable in nature reason: it permits the entry and exit of all materials in and out of the cell.

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Both assertion and reason are true and reason is the correct explanation of assertion.

What is  plasma membrane?

The membrane that divides the interior of the cell from the external environment is known as the plasma membrane, sometimes known as the cell membrane, and it is present in all cells. A cell wall is affixed to the plasma membrane on the exterior of bacterial and plant cells.

Both semipermeable (half permeable) and selectively permeable describe the plasma membrane. It allows for the entrance and escape of some materials from the cell. Additionally, it stops several other materials from moving.

Lipid bilayers called plasma membranes regulate how chemicals enter and leave cells.

Amphipathic phospholipids are the building blocks of the two lipid bilayers that make up plasma membranes. While carbohydrates are affixed to the lipid bilayer's surface, proteins are immersed within it.

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Which feature, viewable in this image, distinguishes cartilage from connective tissue proper? O amorphous matrix O gelatinous ground substance O cells located within lacunae O collagen fibers

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The correct option is C ; Cells located within lacunae, In contrast to other connective tissue, cartilage lacks a direct blood supply and is hence nonvascular.

Cartilage absorbs nourishment and removes metabolic waste via extracellular matrix diffusion.

Connective tissue is made up of cells as well as an extracellular matrix (ECM).

• ECM is made up of structural and specialized proteins that make up the ground material.

• Bounded by the basal laminae of the various epithelia and the basal or exterior laminae of muscle cells and nerve-supporting cells, connective tissue forms a huge and continuous compartment throughout the body.

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According to the graph above, what is the relationship between Helper T Cells and HIV levels
in the body over the course of the infection? Provide an explanation for this trend.

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When a person's CD4 count goes below a particular threshold, they are diagnosed with AIDS.

what are the T helper cells ?

T helper cells (T h cells), commonly known as CD4 + cells or CD4-positive cells, are a kind of T cell that contributes to the adaptive immune system. They help other immune cells function by producing cytokines. They are thought to be necessary for B cell antibody class switching, breaking cross-tolerance in dendritic cells, and activating and growing cytotoxic T lymphocytes.

Helper T cells are essential for immune system function and activate when antigens from disease-causing bacteria are encountered. Antigens are biological markers that allow microbes such as bacteria and viruses to be identified.

When a person's CD4 count goes below a particular threshold, they are diagnosed with AIDS. The treatment recommended by a doctor is determined by the CD4 count.

Continue reading to discover more about T cells and their functions, as well as the relationship between T cell levels and HIV and AIDS.

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The synaptonemal complex with which TEX11 interacts serves as a protein-DNA bridge between what nuclear bodies?
It is the place where chromosomes connect during synapsis (tetrads)

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Since there are currently two unique sister chromatid pairs and a total of four chromatids, the two homologous chromosomes are collectively referred to as a tetrad. Homologous chromosomes physically link at points of intersection known as chiasma during synapsis.

A chiasma is a structure created by cross recombination between two homologous chromosomes. The meiotic process physically connects homologous chromosomes. In other terms, a chiasma is the location where two homologous chromosomes that are not sisters come into touch.What are synapsis and chiasmata?

Answer and justification While chiasma is the point of contact between unrelated chromatids from homologous chromosomes during prophase, synapsis is the pairing of homologous chromosomes during prophase. Synapsis causes chiasm to happen.

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Consider this animal cell. The organelles in an animal cell are labeled. Part D are stacked tubular structures. Which organelles are labeled D, and what is one feature that distinguishes them from the other labeled organelles

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Centrioles; only found in animal cells. The centrioles are cylindrical cellular organelles which are composed of a protein- tubulin and they make up a structure called a centrosome (reulator of cell cycle).

Centrioles are found in almost all eukaryotic cells, (for example, in animal cells and in the male gametes of some plants), but absent from flowering plants and most fungi.

The only organelles that make sugars from sunlight are chloroplasts.

Centrioles are self-replicating organelles found solely in animal cells that are made up of nine bundles of microtubules.

The nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, vesicles, and vacuoles are all organelles found in animal cells. Ribosomes are not surrounded by a membrane, although they are nonetheless referred to as organelles in eukaryotic cells.

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which scenario would result in the highest transmission rates of pathogens among individuals in a group? group of answer choices a small group living in an area where resources are abundant a large group living in an area where resources are abundant a small group living in an area where resources are scarce a large group living in an area where resources are scarce

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A large group living in an area where resources are scarce would result in the highest transmission rates of pathogens among individuals in a group.

The correct option is D.

Transmission is the transfer of a virus that causes a communicable illness from an infected host individual or group to a specific individual or group, regardless of whether the recipient has already contracted the disease. In biology, public health, and medicine, this term is used. The phrase only describes the direct transfer of germs between people via one or more of the following methods:

airborne transmission: Due to tiny, dry, and moist particles that stay around in the air for a long time, contamination can continue to spread even after the host has left. lower than 5 microns in size.

"Droplet transmission" is the term used to describe the movement of small, typically moist particles through the atmosphere. In the presence of the host, contamination frequently happens. 

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What type of selection is it when organisms are genetically best adapted to the environment allowing them to survive and reproduce?

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natural selection is the type of selection when organisms are genetically best adapted to the environment allowing them to survive and reproduce.

Natural selection is the process by which populations of living organisms acclimatize and change. individualities in a population are naturally variable, which means they're all unique in some way. This variation means that some people have traits that are more suited to their terrain than others. individualities with adaptive traits — traits that give them an advantage — are more likely to survive and reproduce. These individualities also pass on their adaptive traits to their seed. These profitable traits come more current in the population over time. Favorable traits are passed down through generations as a result of this natural selection process.

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What are species class 7?

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A species is a group of organisms that are capable of interbreeding and producing fertile offspring. In other words, members of the same species can breed with each other and produce viable offspring.

While members of different species cannot. The concept of a species is used in biology to classify and organize living offspring. There are many different ways to define a species, but the most widely accepted definition is the biological species concept, which defines a species as a group of organisms that can interbreed with one another and produce fertile offspring. Other definitions include the morphological offspring concept, which defines a species based on physical characteristics, and the phylogenetic species concept, which defines a species based on evolutionary relationships.

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What is an organism that obtains energy by feeding on other organisms called?

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An organism that feeds on other living things is referred to as a heterotroph. Because they eat producers or other consumers, heterotrophs are referred to as consumers.

Based on how they receive their energy and nutrients, organisms can be divided into two major types.

Heterotrophs inhabit the second and third levels of a food chain, which is a system of living things that provides food and energy to other organisms. Three trophic levels, which characterize an organism's function in an ecosystem, make up each food chain. The first trophic level is occupied by autotrophs, which include plants and algae. Animals that consume plants—herbivores—live on the second level. Carnivores and omnivores live on the third level . While primary producers are autotrophs, both primary consumers (herbivores) and secondary consumers (carnivores and omnivores) are heterotrophs.

Photoheterotrophs and chemoheterotrophs are the two subgroups of heterotrophs. As they are unable to use carbon dioxide from the atmosphere, photoheterotrophs must still ingest carbon from other organisms in order to maintain their metabolic processes. Contrarily, chemoheterotrophs obtain their carbon and energy from other living things.

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You place a MM moth and a Mm moth on a soot-covered tree trunk. Which one is most likely to be eaten

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An MM and a Mm moth are seen on a tree trunk that has been coated in soot. Most likely, no one will consume either moth. Moths are the collective name for all members of the order Lepidoptera that are not butterflies.

with moths making up the vast majority of the order. Approximately 160,000 distinct species of moth are thought to exist, many of which are still unidentified. Even though there are a few species of daytime and crepuscular moths, nocturnal species are more common. The remaining Lepidoptera, which includes moths, do not form a monophyletic group like butterflies do. A number of natural groupings of the Lepidoptera superfamilies have been attempted, but most of these divisions have been unsuccessful because one of the two groups—Microlepidoptera and Macrolepidoptera, Heterocera and Rhopalocera, Jugatae and Frenatae, and Monotrysia and Ditrysia—is not monophyletic.

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Calculate the rate of movement of the Pacific Plate in cm/year if the distance from Kilauea to Lihue is 450 km.To do this you need to convert km to cm and then calculate the age difference between the volcanoes given.

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If the distance from Kilauea to Lihue is 450 km, then the rate of movement of the pacific plate is 9.7 cm/year.

The problem can be solved by applying the distance concept.

Distance = speed x time

Based on the attached table, the age difference between Kilauea and Lihue volcano is 4.7 million years.

Hence, we can write,

time = age difference = 4.7 x 10⁶ years.

The distance between Kilauea and Lihue is 450 km.

Distance = 450 km = 4.5 x 10⁷ cm

Therefore, the rate of movement of the pacific plate can be considered as the speed.

rate of movement = distance / age difference

                              = 4.5 x 10⁷ cm / 4.7 x 10⁶ years

                              = 9.57 cm/years

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during phosphorylation of stat5b proteins, phosphate groups are exchanged for what atoms on tyrosine residues?

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During phosphorylation of stat5b proteins, phosphate groups are exchanged for  atoms on tyrosine residues-MISSED: Hydrogen atoms in hydroxyl groups

JAK2 is a tyrosine kinase, as the passage mentions. Tyrosine has a nucleophilic hydroxyl group that interacts with the terminal phosphate group (-PO32-) on ATP, which causes an exchange of the hydrogen atom from the hydroxyl group for the phosphate group of ATP. I misread the question; I thought it asked what the phosphate groups would bind to, which would be the oxygen due to nucleophilic attack, rather than what it would replace, which would be the hydrogen, during phosphorylation of stat5b proteins, phosphate groups are exchanged for  hydrogen atoms on tyrosine residues.

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what macromolecule will your body break down first to get atp?

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Carbohydrates are preferred and broken right down to synthesize ATP molecules. Glucose is a key carbohydrate that is metabolized thru glycolysis and undergoes oxidative phosphorylation to generate ATP molecules.

Carbohydrates are observed in a wide array of each wholesome and bad ingredients—bread, beans, milk, popcorn, potatoes, cookies, spaghetti, tender drinks, corn, and cherry pie. in addition they are available in a ramification of paperwork. The maximum common and considerable forms are sugars, fibers, and starches.

Carbohydrates are the body's fundamental fuel source. at some stage in digestion, sugars and starches are broken down into simple sugars. they're then absorbed into the bloodstream, where they're referred to as blood sugar (blood glucose). From there, glucose enters the body's cells with the assist of insulin.

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a researcher is studying two different species. which of the following sets of observations would best support the claim that the two species have structural similarities as a result of convergent evolution? responses genetic similarity function of structure form of structure low same different , genetic similarity function of structure form of structure low same different genetic similarity function of structure form of structure low different same , genetic similarity function of structure form of structure low different same genetic similarity function of structure form of structure high same different , genetic similarity function of structure form of structure high same different genetic similarity function of structure form of structure high different same

Answers

Option A) Genetic Similarity - Low, Function of Structure - Same, Form of Structure - Different is the appropriate response.

Convergent evolution occurs when species have similar-function but different-form analogue body parts. This is not present in ancestors because it is a characteristic that they independently developed, making genetic similarity low. Convergent evolution is the process by which two organisms with no recent common ancestor become increasingly similar as they adapt to the same ecological niche. The organisms' convergent phenotypes are known as analogous structures, and they have similar structural forms (such as bird wings and bat wings). It is the independently occurring evolution of traits that are shared by species across historical eras.

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which of the choices is the diffusible extracellular element in the process of vulval cell differentiation in c. elegans?

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The extracellular matrix has no influence on the cells it envelops. The polysaccharides in the extracellular matrix influence the cell's growth size.

Which cell junction is involved in the formation of a barrier between cells?

Tight junctions close gaps between cell membranes, enhancing an internal cavity's selectivity by forming a strong barrier against fluids and ions. Tight connections constitute the blood-brain barrier. Gap junctions, on the other hand, create microscopic holes to join neighbouring cell cytosols.

As a result, integrins are kinases. Integrins are ligands and extracellular matrix proteins are receptors.

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What is it called when the ventricles relax and blood pressure at lowest?

Answers

Diastole is the relaxed phase of the cardiac cycle when the chambers of the heart are re-filling with blood.

When does blood pressure drop and the ventricles relax?

The ventricles start to relax after ventricular repolarization, and their internal pressure decreases. One heart cycle is marked by the passage of blood from the atria into the ventricles when the pressure falls below that of the atria, opening the atrioventricular valves.

What is the ventricle relaxing known as?

During both the diastole and systole, the ventricles pump. The cardiac cycle, which includes all of the activities that take place between the start of one heartbeat and the start of the next, can be split into two phases: a relaxation phase known as diastole and a contraction phase known as systole.

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Force f acts between a pair of charges, q1 and q2, separated by a distance d. for each of the statements, use the drop-down menus to express the new force in terms of f. q1 is halved, q2 is doubled, but the distance between the charges remains d. q1 and q2 are unchanged. the distance between the charges is doubled to 2d. q1 is doubled and q2 is tripled. the distance between the charges remains d. what information might you want to know about the perspective of the author or publishers of the chicago herald? question 24 options: a) firms want to borrow less for new plants and equipment and households want to borrow less for homebuilding. b) firms want to borrow less for new plants and equipment and households want to borrow more for homebuilding. c) firms want to borrow more for new plants and equipment and households want to borrow less for homebuilding. d) firms want to borrow more for new plants and equipment and households want to borrow more for homebuilding. To supplement (compile) the list of documents for the period 2019-2022. (using information from official websites):1) Regulatory and legal regulation of project activities in the OIV of the Russian Federation (2019-2022);2) Methodological recommendations on projects in the Russian Federation (2019-2022);3) Regional regulatory legal acts and methodological recommendations (Krasnodar Territory) triangle ABC was translated 4 units to the left and 3 units down. write the rule that describes the transition that was applied to the triangle ABC to create triangle ABC write a c program named printoneexpression that will read in an expression and print out its formatted one with correct result. Which technique is performed on the surface of the hair to create a highlighted or low lighted color effect?Freeform paintingA highlighting technique in which a crochet hook is used to pull hair strands through a perforated cap is called:Cap methodWhich coloring technique is used to ensure the product thoroughly penetrates the entire strand?Base to endsWhich of the following techniques is generally referred to as a retouch application?BaseA technique popular with clients who request ombr is:Away from the base coloring Arturo Merino Bentez International Airport is the primary method of entry into Chile, located in Chile's capital and largest city of Santiago. As of 2020, it was the third busiest airport in South America. true or false If 16, x, 1, y are in Geometric Progression, find the product of x and y. Find three countries that have experienced negative population growth in 2017. a nurse is caring for a client recovering from a hypophysectomy. what would be included in the client's care plan? select all that apply. Solve the word problem completely. Determine also the kind of proportion used what rhetorical device were the declarations signers using when they used strong emotion words to describle the grivevances againsnt the king What is the length of segment AB? Pa help po!Nonesense-REPORT Which type of pressure suppresses weather development?answer choicesHigh PressureLow PressureMixed PressureNo Pressure Suppose the Fed announces that it is raising its target interest rate by 50 basis points, or 0.5 percentage point. To do this, the Fed will use open-market operations todecrease thesupply of money by selling bonds to the public. The traditional and life-span perspectives are contrasting views of developmental change. According to the life-span perspective, when do developmental changes occur?A.during infancy and early childhoodB.during adolescence and early adulthoodC.during middle and late adulthoodD.throughout the entire life cycle Which of the following correctly places one need before another, according to Maslow's hierarchy of needs Draw the polygon with the given vertices in a coordinate plane.22).(-5,5),(-4,1) pls help