what is the mechanism of action of grapiprant?

Answers

Answer 1

Answer:

Grapiprant has been accepted very greatly in veterinary as its mechanism of action is a targeted approach to pain management by not having any interaction with the production of prostanoids and thus, by not interacting with other prostaglandin receptor pathways

Answer 2

Grapiprant, also known as AT- 001 and CJ- 023, is a medicine from the piprant class.

These motes were deduced from acyl sulfonamide and are characterized to be a new series of para N-acyl amino methyl benzoic acid known to be prostaglandin receptor antagonists. This type of motes is presently in development for veterinary cases. This class of medicines as defined in 2013 by the World Health Organization. Grapiprant has been approved in March 2016 by the FDA's Center for Veterinary Medicine as anon-cyclooxygenase inhibiting NSAID for veterinary use.

mechanism of action of grapiprant-

Grapiprant is an EP4 prostaglandin receptor antagonist and therefore the exertion of this medicine is allowed to be fully related to the picky leaguer of this receptor.1 It binds to mortal and other mammals' EP4 prostaglandin receptor with high affinity without snooping with other prostaglandin pathways which are important for a variety of physiological functions. The list of laropiprant blocks the PGE2 list and hence its natural effect related to the signaling pain and inflammation waterfall.Grapiprant has been accepted veritably greatly in veterinary as its medium of action is a targeted approach to pain operation by not having any commerce with the product of prostanoids and therefore, by not interacting with other prostaglandin receptor pathways.

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Related Questions

who is responsible for determining the safety and efficacy of any dietary supplement?

Answers

Answer:

The manufacturer of the supplement / Food and Drugs Administration (FDA)

The manufacturer of the drug is responsible for determining the safety and efficacy of any dietary supplement.

Which body is responsible for determining the safety and efficacy of any supplement?

Although it is the FDA's responsibility to take action upon discovery of an adulterated or dietary supplement after reaching the market, the responsibility to determine the safety and efficacy of the supplement is on the manufacturer of the product.

Hence, the manufacturer is responsible for determining the safety and efficacy of the dietary supplement.

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Which section of this label shows the nutrients that should be limited when considering dietary guidelines

Answers

The nutrients that must be confined while thinking about nutritional recommendations are Saturated fat, sodium, and delivered sugars which might be related to detrimental fitness effects.

What is Dietary Guidelines ?

The Dietary Guidelines represents recommendation on what to consume and drink to fulfill nutrient needs, sell fitness, and save you disease.

It is advanced and written for a expert audience, which include policymakers, healthcare providers, nutrients educators, and Federal nutrients software operators.

Hence, According to Dietary recommendations, the vitamins that must be confined are Saturated fat, sodium, and delivered sugars which might be related to detrimental fitness effects.

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Alex is trying to make healthier eating choices. While at a restaurant, Alex has several protein options to choose from. Which protein choice is the healthiest option?

Answers

Answer:

grilled tuna

Explanation:

Grilled tuna has a high protein content. A can of tuna has 43 grams of complete protein, including all necessary amino acids.

a client has a medical diagnosis of an advanced first-degree atrioventricular block and is symptomatic. what initial treatment will the nurse be prepared to complete?

Answers

The initial treatment that the nurse must be prepared to complete is; Permanent Pacing

What is the right medical treatment?

First-degree atrioventricular (AV) block is a condition of abnormally slow conduction through the AV node. This condition is defined by ECG changes that includes a PR interval of greater than 0.20 without disruption of atrial to ventricular conduction.

Now, usually first degree atrioventricular block requires no treatment but when it becomes worse, what should be administered is called Permanent pacing which  is the therapy of choice in patients with symptomatic atrioventricular (AV) block with bradycardia.

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Match the health related components of fitness to the appropriate example.

Body Composition

Answer 1
Running a Marathon
Aerobic Endurance

Answer 2
Limitless activities that help the ratio of lean muscle to fats in the body
Muscular Strength

Answer 3
Finishing a set of 100 consecutive sit ups
Muscular Endurance

Answer 4
Squatting a 400 lb barbell
Flexibility

Answer 5
A forward fold hamstring stretch

Answers

Health-related physical fitness refers to the physical condition in capacities that are deeply related mainly to people's quality of life, being flexibility, aerobic resistance, strength and body composition.

What are health-related physical fitness?

the five components of physical fitness related to health are:

muscular strengthmuscular endurancecardio-respiratory resistanceflexibility and body compositionshowing their conceptsclassificationsinfluencing factors and their importance for health.

body composition

answer 1

Running a Marathon - Muscular Endurance

answer 2

Unlimited activities that help with the ratio of lean mass to fat in the body

answer 3

Finish a set of 100 consecutive sit-ups - Aerobic Endurance

answer 4

Squatting a 400 lb bar - Muscle strength

Answer 5

A Forward Bend Hamstring Stretch - Flexibility

With this information, we can conclude that health-related physical fitness refers to the physical condition in capacities that are deeply related mainly to people's quality of life, being flexibility, aerobic resistance, strength and body composition.

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if the facility does not have an electronic decision support system in place, which sources would nurses seeking answers to clinical questions consult first?

Answers

If the facility does not have an electronic decision support system in place, nurses seeking answers to clinical questions would consult research summaries.

What is a research summary in healthcare?

A research summary is a piece of writingwhich briefly summarizes the findings as well recommendations basedon the research.

A research summary would provide nurses with relevant information about clinical questions based on research done on those areas.

Therefore, nurses should consult research summaries when seeking answers to clinical questions.

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Larry wants to hold an event that covers dual special needs plans (dsnp). he will use the slide presentation provided by unitedhealthcare to explain the plan benefits and will help consumers complete enrollment applications at the end. what type of event does larry need to conduct?

Answers

In this scenario, the type of event that Larry need to conduct is a marketing/sales event formal.

A formal sales event is one when a salesman addresses the audience and provides them with specific information, sales presentations, or talking points.

Therefore, Larry has to hold a formal marketing/sales event to describe the plan benefits and assist customers with filling out signup forms.

Powerful Marketing Strategies To Grow Your Business Faster:

#1. Set a Goal and a Budget.

#2. Build Your Influence.

#3. Leveraging Employees as Thought Leaders.

#4. Champion One Social Channel.

#5. Build Rapport through Email.

#6. Blog Strategically.

#7. Conduct Research That Impacts Your SEO.

#8. Teach Others.

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What organization currently provides voluntary accreditation of healthcare organization

Answers

Answer:

The Joint Commission

Hope you have a great day :)

A method of transferring a patient from bed to stretcher, during which two or more rescuers curl the patient to their chests then reverse the process to lower the patient to the stretcher, is:

Answers

The method of transferring a patient from bed to stretcher, during which two or more rescuers curl the patient to their chests then reverse the process to lower the patient to the stretcher, is called direct carry.

What is patient care?

Patient care refers to the process of providing care to a sick patients in the hospital.

Patient care is a part of health care.

Sometimes, patient care requires that patients are moved by means of a stretcher as they are not able to move on their feet.

One method of transferring a patient from bed to stretcher is called direct carry.

In this method, two or more rescuers curl the patient to their chests then reverse the process to lower the patient to the stretcher.

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_____ is the art and science of trying to get people to do what you want (dok 1, standard standard 2.1.n evaluate internal and external influences that affect food choices.) testimonial salience persuasion repetition

Answers

The word you’re looking for here is persuasion. In persuasion, people try to convince others of something or sway them toward a suggested belief about something. This is commonly used in manipulation too.

Persuasion is the art and science of trying to get people to do what they want. So the correct option is C.

What is Persuasion?

The art of Persuasion is the practice to encourage people to accept something that we want them to accept or to do something that we want them to do. For some people, persuasion is an inherently natural quality to them and for others, it is an art that they perfect in my practice.

The art of persuasion is a powerful skill that an individual can learn. It is a valued skill for an employee to have as an employee with this skill can excel at several aspects of their job.

The skill of persuasion directly impacts leadership skills and teamwork skills which are highly valuable, not only in the workplace but in several other aspects of life.

Persuasion skills can be learned by observation of others and by understanding how they navigate through disagreements to ultimately persuade someone according to their own choice.

Therefore the correct option is C.

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You are alone and have identified a child who is not responsive. You have performed chest compressions for 2 minutes. What is the next step in CPR?
A. Try to find a pulse.
B. Call 911.
C. Continue chest compressions.
D. Go get help

Answers

B.

Call 911

Explantation:

a nurse is preparing to administer a drug. upon reading the medication guide, the nurse notes that the drug has been linked to symptoms of parkinson’s disease in some patients. what will the nurse do?

Answers

The nurse should inform the doctor in order to consider appropriate steps to take.

What is a medication guide?

A medication guide is an information usually written in paper about how a medication should be administered as well as the interactions and probable sideeffects of the medication.

Since the medication has been linked to symptoms of parkinson’s disease in some patients, it is appropriate that the nurse inform the doctor in order to consider appropriate steps to take.

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How do advertisements you see on television or the Internet influence you to want to buy a certain product? How do you decide whether to buy the product? (6 points)

Answers

Pricing and whether the product actually works are my determine factors. I am usually interested in self care products.

A diet deficient in calcium can lead to which condition?

Answers

Based off the context, either hypocalcemia or osteoporosis.

Osteoporosis:

A disorder in which the bones become increasingly porous, brittle, and subject to fracture, owing to loss of calcium and other mineral components, sometimes resulting in pain, decreased height, and skeletal deformities: common in older persons, primarily postmenopausal women, but also associated with long-term steroid therapy and certain endocrine disorders.

Hypocalcemia:

An abnormally small amount of calcium in the blood.

Lack of context. So I can provide this.

Hope this helps.

hypocalcemia which means below (hypo) (calc) calcium

Prep is taken _______________________________ possible hiv exposure. 72 hours after 96 hours after everyday prior to the day of to

Answers

Prep is taken 72 hours after possible HIV exposure in individuals.

What is Prep?

This is referred to as pre-exposure prophylaxis and it reducers the chances of contracting HIV after exposure through sex etc.

This medication however should be taken within 72 hours of exposure for adequate action.

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you have been approached to help start an anti-bullying club at school. what would an on-campus, school club do to promote an anti-bullying environment?

Answers

Answer:

to help start an anti-bullying club at school, an on-campus, school club can start by educating a group of people on the negative effects and disadvantages of bullying. Then the group can go on and convince others to join, and little by little the campaign will expand and people will start to understand and practice kindness and love among themselves.

I would most definitely lead by example as far as that goes.. it’s ok to move in different ways and circles and still be able to help and coexist as well.. I’m humble myself but far from a cupcake sweetheart lol but my current situation enlightened me on the ones that I can rely on and exchange my all to.. don’t me I don’t love or respect em..I’m just saying that I move different and think differently than a lot of people.. I say be able to be yourself and keep your mind open and instead of judgment especially when it’s not good or important to do so u should talk to that person but regardless remember to stay humble and and forgive and help when you can

What specific kind of pathogen is hiv? a bacteria called an antibacteria a parasite called an anti parasite a virus called a provirus a virus called a retrovirus

Answers

Answer:

retrovirus

Explanation:

a retrovirus inserts RNA to produce the viruses DNA in the hosts cells

this is why mothers can pass HIV and other retroviruses through pregnancy or breastfeeding

A virus called a retrovirus is a specific kind of pathogen that is HIV.

What is a retrovirus in simple terms?

A type of virus that contains RNA instead of DNA as a genetic substance. It uses an enzyme called reverse transcriptase to become part of the host cell's DNA.

In addition to the AIDS-causing virus, the human immunodeficiency virus (HIV), there are two retroviruses that can cause illness in humans. One is called human T-lymphotropic virus type 1 (HTLV-1) and the other is called human T-lymphotropic virus type 2.

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Once someone serves in tennis, if the receiver manages to return the ball, this phase is called a _______.

Answers

The answer is return ace

Activity 1 think of any programs you know about non-communicable disease (ncd). write down words or phrases that associates with ncd.

Answers

The word Non - communicable disease refers to the group of disorders or diseases which are non contagious or non infectious .

As non-communicable disease occurs due to genetic , environmental , physiological or lifestyle changes these are not passed from person to person, so these lasts for a longer period of time (chronic diseases) . Examples of these type of conditions are : diabetes , Alzheimer , cancers , asthma or any mental health conditions and respiratory diseases . These diseases can be aggravated by tobacco or cigarette use , unhealthy diets and sedentary lifestyle (physical inactivity ).

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Luca is thinking about joining a gang because of challenges in his current family environment. Which situation most likely influenced his decision?

He does not have any friends at school.
He needs to help bring in money at home.
His cousin has a history of depression.
He feels hopeless about life and his future.

Answers

Answer:

He needs to help bring in money at home

Explanation:

Gang = drugs = money (like a lot of it)

If this is for Plato the correct answer is D, he feels hopeless about life and his future

Which condition has the highest measure of aggressive behavior among childhood disorders?
A. Attention Deficit Hyperactivity Disorder
B. Autism
C. Bipolar disorder
D. Conduct Disorder
E. Oppositional Defiant Disorder

Answers

Conduct Disorder has the highest measure of aggressive behavior among childhood disorders. Why? Well, the definition itself is explanatory. Conduct disorder is a mental illness in which children specifically present themselves in an aggressive manner, meaning they have tendencies to commit theft, lie, bully, and intimidate. Children with conduct disorder are not very attentive; they disregard general rules and lack empathy and social acceptable behavior. This is most of the time a result of how they were treated or if anything happened to them traumatically such as brain damage.

The plasma membrane of cells lining the small intestine has ___________ which are specialize for absorption of nutrients

Answers

The plasma membrane of cells lining the small intestine has villi which are specialize for absorption of nutrients.

What is villi?

Villi is small projection from a membrane, particularly those found in the mucous membranes of the intestines.

The small intestine is the known to be the site of absorption of nutrients in humans and other living organisms.

This is because the plasma membrane of cells lining the small intestine has villi which are specialize for absorption of nutrients.

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hich initiatives are pillars of the Let’s Move! program? Select three options.

increasing physical activity
providing more snack times in schools
creating a healthy start for children
empowering parents and caregivers
providing children with vitamin supplements

Answers

1. Creating a healthy start for children
2. Empowering parents & caregivers
3. Increasing physical activity

The following initiatives make up the lets move program's cornerstones:

raising the level of exercise

giving children a healthy start

enhancing parental and caregiver control.

thus option A, C and D initiatives are pillars of the Let’s Move! program.

How do the let's move program work?

This might be referred to as a public health initiative that was started by Michelle Obama, the former first lady of the United States.

The program's goal was to combat childhood obesity in early childhood and encourage them to maintain a healthy lifestyle.

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jan likes dan. dan shows signs of flirxting with jan, but also sort of flirxts with mary. dan talks to jan more, though. who does dan like, or is there something differenta?

Answers

Answer:

well if Dan talks to Jan more it's most likely to be Mary that he likes because he hasn't talked to Mary which could be a sign of shyness . and if he talks to Jan more he is used to her or more comfortable with her he could also like Jan since he's talking to her more. it's a 50/50 chance with both

I hope this helped 70% confident about my answer

The ____consists of the fibers that surround the medulla.

cortex
follicle
bulb
cuticle
helpp

Answers

Answer: cortex

 

learned it a year ago

Answer:

The cortex consists of the fibers that surround the medulla.

In 1990, three out of the top seven causes of death around the world were NCDs, but by 2015 that number grew to ____ out of the top seven causes of death.

Answers

In 1990, three of the seven leading causes of death worldwide were NCDs, but by 2015 this number had grown to 5 of the seven leading causes of death.

What are the main NCDs?

Non-communicable chronic diseases (NCDs) are the leading cause of death and disability worldwide. They include five major disease groups:

cardiovascularchronic respiratorycancerdiabetesand mental and neurological conditions.

With this information, we can conclude that in 1990, three of the seven leading causes of death worldwide were NCDs, but by 2015 this number had grown to 5 of the seven leading causes of death.

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A+serving+of+food+that+has+10%+to+19%+of+a+nutrient+based+on+a+2,000-calorie+diet+is+considered+to+have+__________

Answers

A serving of food that has 10% to 19% of a nutrient based on a 2,000-calorie diet is considered to have good nutritional value.

What is nutritional value?

Nutritional value is the amount of nutrients that can be found in a particular food.

The nutritional value depends on quantity of a food which is digested and absorbed and the amounts of the essential nutrients it contains.

Am average adult should consume up to 2000 calories per day

Therefore, a serving of food that has 10% to 19% of a nutrient based on a 2,000-calorie diet is considered to have good nutritional value.

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my guy friend is asking me if he dated a they/them, would that make him g.ay? If you was a trans male, I didn't know the answer and my friends were ghosting me, can anyone help?

Answers

Answer:

yes it would make him g.ay

Explanation:

If you didn't know it was a guy then no your not g.ay if you did and you dated it any it would make you g.ay

My question is did your fre

friend know or just found out and dated it anyway

I don’t know how to fill this out HOPE

Answers

It should be just enough to increase the stretch in the quad. Hold for 2 seconds then straighten the knee. Perform 10-15 repetitions.

Explanation:

if it doesn't help add me on discord EthDaGamer#0980

If you have 4 45 plates and a 45 pound bar how heavy is that

Answers

the answer that ur looking for is 225

Answer:

225

Explanation:

45x4=180

180+45=225

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The revenue from selling shirts is r(x) = 11x.The cost of buying x shirts is c(x) = 6x + 20. The profit from selling x shirts is p(x) = r(x) - c(x). What is p(x)? Which excerpt most clearly suggests that George and Hazel are living in adystopian society in the story "Harrison Bergeron"? A fold shaped like an elongate trough is a(n) Which characteristics does Gilgamesh display in this passage? Check all that apply. Laurie is trying to stay within 10 feet of her current diving depth of 30 feet (with regard to sea level) so that the light is still good but she can be close to the sea life during her scuba dive. Which two equations can be used to find the minimum and maximum depths Laurie wants to stay between?-30 - x = 10 and -30 - x = 10-30 + x = 10 and -30 + x = 10x + 10 = 30 and x + 10 = 30x 10 = 30 and x 10 = 30 Who introduced the ideas of mesopotamia x/x-2 + x-1/x+1= -1Can someone walk me through the steps of this problem? Much appreciated. :) find the roots of x^4-1=0 The number of goldfish in a tank is 22, and the volume of the tank is 56 cubic feet. What is the density of the tank?. What is the definition of the word ''Dimension'' In the equation below, variables X and Y represent two matrices. Which property of matrix addition is illustrated below?X+Y=Y+XO inverse propertyO commutative propertyO associative propertyO identity property A scuba diver uses compressed air to breath under water. He starts with an air volume of 3.20 L at sea level (1 atm) at a temperature of 30C. What is the volume of air in his tank at a depth of 100 ft (3 atm) and a temperature of 24C? Which source would be most appropriate for researching the question "How does social media affect personal relationships?a blog post discussing the bloggers large number of followersa journal article by a psychologist who is studying social mediaa social media site showing the process of connecting to other usersa wiki page discussing appropriate interactions on the internet Help please I need asap What type of graphic organizer would best represent the connection between these two ideas? a t-chart that separates ideas into two different categories a chronology that shows a sequence of several events a cause-and-effect graphic that shows how one idea led to another a problem-solution graphic that presents a problem and a solution to the problem 1. EL precio a la venta de una impresora de inyeccin de tinta es de $285.000 incluida una Ganancia del 35%. cunto le cuesta a la tienda cada impresora? A good summary of an informational text must Strong writing often uses figurative language. Metaphors are a good way to describe characters, places, actions, and feelings. For this task, you will write a paragraph that contains three metaphors. Remember, a metaphor is a direct comparison. Type your paragraph in the essay box. Review your writing for correct punctuation, spelling, and grammar. Quadrilateral VWXY is a parallelogram. Find the measure of V A shark has a special kind of camouflage called countershading. Its back and stomach are different colors. The shark is darker on its back and blends with the dark water below it. Predators cant see it from above. The shark is lighter on its stomach and blends in with the lighter water above. The sharks prey near the ocean bottom cant see it above them.Which sentence from the passage BEST supports the idea that a shark's camouflage helps make it an excellent predator? A. "A shark has a special kind of camouflage called countershading." B. "Its back and stomach are different colors." C. "Predators cant see it from above." D. "The sharks prey near the ocean bottom cant see it above them."